CAS: 626-15-3; 1,3-Bis(Bromomethyl)Benzene

上下游产品

1,3-dimethanol benzene carbon tetrabromide m-xylene isophthalic aldehyde dihydrazone 1,3-bis-piperidinomethyl-benzene 1,1'-bis(pyridinium)-1,3-phenyldimethylene dibromide m-xylylenedioxy-bis-pyridinium; dibromide1,1'-m-xylylenedioxy-bis-pyridinium; dibromide m-xylylene-bis-pyridinium; dibromide3,3'-dihydroxy-1,1'-m-xylylene-bis-pyridinium; dibromide

间二甲苯置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,化学反应生成 间二溴苄
参考文献:同型双季杂环杂环铵盐作为有效的乙酰基和丁酰胆碱酯酶抑制剂:系统的研究的连接和阳离子头对亲和力和选择性的影响.
标题:同型双季杂环杂环铵盐作为有效的乙酰基和丁酰胆碱酯酶抑制剂:系统的研究的连接和阳离子头对亲和力和选择性的影响.
摘要:季铵盐(qass)的分子库,主要由具有胆碱激酶(chok)抑制活性的对称双季铵溴化物组成,评估了它们抑制乙酰胆碱酯酶和丁酰胆碱酯酶的能力(分别为ache和bche).qas的分子框架由两个带正电荷的杂芳族(吡啶或喹啉鎓)或空间受阻的脂肪族(喹啉鎓)氮环通过亲脂性刚性或半刚性接头保持适当的距离组成.许多同二聚体qas在纳摩尔范围内显示出ache和bche抑制能力,并且酶选择性低.关于ache,Bche,56)表现出最高的ache亲和力(ic 50 = 15 Nm)和选择性超过bche和chok(分别为si = 50和562),并且在重症肌无力和神经肌肉阻滞中有希望的药理潜力.
DOI:10.1021/jm101299D

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:WO-2008148560-A1
优先权日:2007-06-07
标题 :New hybrid compounds of nucleobases and organic redox molecules and their use
发明人：ASAFTEI SIMONA CARMEN
权利人:UNIV OSNABRUECK; ASAFTEI SIMONA CARMEN
摘要:The present invention relates to new compounds as well as methods for the synthesis of the same, said compounds comprise a redox active group, e.g. a 4,4-bipyridine (viologen), a 1,2-di(4-pyridyl)ethane, a 2,7-diazapyrene or 2,9-diazaperylene group and a N-heterocyclic nucleobase (HB), also referred to as base.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.