2-甲基戊烷 以61%的收率获得产物2-氨基丁醇 参考文献:Amino Alcohol Derivatives,Method Of Producing Said Derivatives And Medicaments Containing Them 标题:Amino Alcohol Derivatives,Method Of Producing Said Derivatives And Medicaments Containing Them 摘要:式i的化合物 其中 R1代表氢或甲基 R2代表1至10个碳原子的较低直链或支链烷基 R3代表氢或较低烷基 N代表0-12 R4代表具有6至24个碳原子的烷基,烯基或炔基,以及用于骨质疏松症治疗的含有这些化合物的制备方法和药物.
专利号:US-2006058532-A1 优先权日:2004-09-10 标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives 发明人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A 权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A 摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.
专利号:US-5591867-A 优先权日:1992-12-04 标 题 :Synthesis of kainic acid 发明人:MONN JAMES A 权利人:LILLY CO ELI 摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.
专利号:US-2001047100-A1 优先权日:2000-04-26 标 题:Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives 发明人:KJAERSGAARD HANS JOERGEN; PHILLIPS JIM; ALI SYED M 摘要:Novel intermediates useful in the preparation of optically active H 3 histamine receptor antagonist 2-(4-imidazoyl)-cyclopropyl derivatives are disclosed.
专利号:WO-2008059051-A1 优先权日:2006-11-16 标 题 :Synthesis of imide compounds 发明人:CAILLE JEAN-CLAUDE; HII KING KUOK MIMI 权利人:PPG INDUSTRIES INC; IMP INNOVATIONS LTD; CAILLE JEAN-CLAUDE; HII KING KUOK MIMI 摘要:The invention relates to a process for the production of an imide (1) (2) (3) via the enantioselective addition of an amine (2) to an alkene (3) wherein Y is OR, wherein R is alkyl or Bn, said process comprising: incubating Pd(OTf)2 with a phosphine ligand comprising one or more chiral biaryl groups to form an asymmetrical catalyst in situ; and adding the amine (2) and the alkene (3) to the in situ generated catalyst to form an imide (1). The invention provides better enantioselectivity with good yield
专利号:US-7078532-B2 优先权日:2001-04-30 标 题:Process for manufacture of fosinopril sodium 发明人:DUBEY SUSHIL KUMAR; LAHIRI SASWATA; SINGH ANIL VIR 权利人:LUPIN LAB LTD 摘要:The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the desired isomer from the mixture through formation of alkali metal salts followed by crystallisation.
专利号:US-9718807-B2 优先权日:2012-06-05 标 题 :Synthesis of antiviral compound 发明人:SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE 权利人:GILEAD PHARMASSET LLC 摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.
[参考文献]: Rym Hassani, Et Al. New Chiral 4-Substituted 2-Cyanoethyl-Oxazolines: Synthesis And Assessment Of Some Biological Activities. Chem Biol Interact. 2014 Jun 25:217:41-8.
合成参考文献
摘要:Pajkert, R.; Röschenthaler, G.-V., Science of Synthesis Knowledge Updates, (2022) 1, 369. 摘要:Bertau, M.; Jeromin, G. E., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 161. 摘要:Hollmann, F., Science of Synthesis Knowledge Updates, (2021) 3, 437.