CAS: 56881-31-3; 7-Aminothieno[2,3-B]Pyrazine-6-Carboxylic Acid

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244014-85-5 56881-21-1 2123445-28-1

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CAS号56881-21-1 7-氨基噻吩并[2,3-b]吡... | CAS号55557-52-3 2-氯-3-氰基吡嗪 | CAS号59944-75-1 噻吩并[2,3-b]吡嗪-7-胺

合成工艺路线路线简述

    📜2-氯-3-氰基吡嗪置于水,Sodium Carbonate,Potassium Hydroxide体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 6.5H,反应生成 7-氨基噻吩并[2,3-B]吡嗪-6-羧酸
    参考文献: Thieno (2,3B) Pyrazine Compounds As B-Raf Inhibitors[fr] Composés Thiéno(2,3B)Pyrazine En Tant Qu'Inhibiteurs De B-Raf
    标题: Thieno (2,3B) Pyrazine Compounds As B-Raf Inhibitors[fr] Composés Thiéno(2,3B)Pyrazine En Tant Qu'Inhibiteurs De B-Raf
    摘要:该发明涉及符合一般式(i)或其药学上可接受的盐的化合物.这些化合物可用于治疗癌症.

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    专利信息


    专利号:US-4833271-A
    优先权日:1985-08-23
    标 题 :Structurally defined oligomers and preparation thereof for the protection of oxidative phosphorylation and which exhibit ionophoretic activity
    发明人:NELSON GEORGE L
    权利人:NELSON GEORGE L
    摘要:Structurally-defined, low molecular weight oligomers and preparation thereof which are active in the protection of oxidative physphorylation of mitochondria and exhibit ionophoretic activity. Said structurally defined low molecular weight oligomers are synthesized using a modified 15-dehydro PGB1 such as 16,16-dimethyl-15-dehydro prostaglandin B1 as a precursor to obtain oligomeric mixtures which are structurally defined and active in the protection of oxidative phosphorylation and exhibit ionophoretic activity. Synthesis of modified 15-dehydro-PGB1; 16,16-dimethyl-15-dehydro-prostagalandin B1; is also described.

    专利号:CN-118290286-A
    优先权日:2023-01-03
    标题 :Synthesis method of high-steric-hindrance amide

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/cb400400j
    摘要:Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, LaVoie EJ, Das K, Arnold E. Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol. 2013 Nov 15;8(11):2501–8.
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