CAS: 53772-83-1; Zuclopenthixol

上下游产品

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 2-Chlorothioxanthone 1,2-propanediene 2-bromoethanolzuclopenthixol acetate

📜Tert-Butyl 4-(Benzoyloxy)Piperazine-1-Carboxylate,2-氯噻吨酮,丙二烯,2-溴乙醇置于copper Diacetate,R-(+)-1,1'-联萘-2,2'-双二苯膦,甲基二甲氧基硅烷体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.08H,以4.762%的收率获得产物
参考文献:使用丙二烯(石油裂化副产物)的对映选择性烯丙基化
标题:使用丙二烯(石油裂化副产物)的对映选择性烯丙基化
摘要:丙二烯 (C3H4) 气体在石油精炼过程中以每年百万公吨的规模生产和分离,但很少用于有机合成.同时,向酮添加烯丙基 (C3H5) 是合成化学中最常见和最典型的反应之一.在此,我们报告了丙二烯气体与廉价且对环境无害的氢硅烷(如 Pmhs)的组合,可以替代大多数对映选择性酮烯丙基化反应所需的化学计量数量的烯丙基金属试剂.该过程由铜盐和市售配体催化,无需专门设备或加压即可运行,并且可耐受广泛的官能团.此外,
DOI:10.1021/jacs.8B13907

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).

专利号:US-2012232225-A1
优先权日:2009-08-26
标 题:Synthesis and isolation of dendrimer systems
发明人：BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL
权利人:BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

专利号:US-9402911-B2
优先权日:2011-12-08
标题:Multifunctional small molecules
发明人：BAKER JR JAMES R; HUANG BAOHUA M; THOMAS THOMMEY P
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.

专利号:US-8912323-B2
优先权日:2009-10-30
标题 :Multifunctional small molecules
发明人：BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P
权利人:BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P; UNIV MICHIGAN
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.

专利号:US-2014303123-A1
优先权日:2011-11-22
标 题:Synthesizing functionalized dendrimers within biological settings
发明人：BAKER JR JAMES R; GOONEWARDENA SASCHA NILU; ZONG HONG
权利人:UNIV MICHIGAN
摘要:The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.