CAS: 4521-33-9; 5-Nitrothiophene-2-Carboxaldehyde

该化合物是一种有机化合物,其特点是存在硫环,硝酸盐组和一个甲酰胺功能组,其分子结构中含有五人芳香环,含有硫磺,有助于其独特的化学特性.硝酸盐组(-NO2)是一种电离脱色的替代结构,能够影响化合物的再活性,使其在各种合成应用中有用.甲酰胺组(CHO)是反应性的,可以参与凝聚反应,使该化合物在有机合成中具有价值.5-Nitro-2-thiopheneboxalthyde,通常是一种黄色至褐色固态的芳香环,在有机溶剂中可溶解.它经常用于合成药物,农业化学品和其他精密化学品,因为其有能力进一步进行化学转化.在处理该化合物时,应当采取安全防范措施,因为硝基化合物是危险的.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号98-03-3 2-噻吩甲醛 | CAS号20898-85-5 2-(羟甲基)-5-硝基噻吩 | CAS号14289-24-8 Methanediol,1-(... | CAS号63011-97-2 (乙酰基氧基)(2-噻吩)乙酸甲酯 | CAS号20898-83-3 (5'-nitro-2'-th... | CAS号20409-48-7 2-(三甲基乙酰基)噻吩 | CAS号87207-23-6 2,2-dimethyl-1-... | CAS号83054-95-9 2,2-dimethyl-1-... | CAS号20898-86-6 2-氯甲基-5-硝基噻吩 | CAS号87207-17-8 2-(1'-chloro-2'... | CAS号14903-93-6 5-Pyrimidinecar... | CAS号39978-57-9 5-硝基噻吩-2-羰基氯 | CAS号18922-31-1 3-(5-nitrothiop... | CAS号20898-86-6 2-氯甲基-5-硝基噻吩 | CAS号6317-37-9 5-硝基噻吩-2-羧酸 | CAS号5832-01-9 5-硝基-噻吩-2-甲酸甲酯 | CAS号31271-13-3 5(4H)-Oxazolone... | CAS号33389-33-2 1,2-二氢-2-(5-硝基-... | CAS号33372-40-6 4-(2,3-DIHYDROX... | CAS号33389-36-5 4-(2-HYDROXYETH...

合成工艺路线路线简述

  • 合成目标产物 5-Nitrothiophene-2-Carboxaldehyde 主要起始原料 5-Nitrothiophen-2-Ylmethylene Diacetate
  • (文献来源)合成步骤主要原料 5-Nitrothiophen-2-Ylmethylene Diacetate
(5-硝基噻吩-2-基)甲醇置于silica-Supported Jones Reagent体系中,用 二氯甲烷 作为反应溶剂,以99.8%的收率获得产物5-硝基噻吩-2-甲醛
参考文献:在压力驱动的流动反应器中使用二氧化硅负载的琼斯试剂对芳香醇进行清洁和选择性氧化
标题:在压力驱动的流动反应器中使用二氧化硅负载的琼斯试剂对芳香醇进行清洁和选择性氧化
摘要:通过利用连续流动反应器中获得的高表面积体积比,我们能够根据所使用的流速将一系列伯醇选择性地氧化为醛或羧酸,证明了在传统搅拌条件下无法实现的反应控制程度反应堆.
DOI:10.1016/j.Tetlet.2006.05.157

海关参考信息

专利信息


专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人:LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人:FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:US-9949970-B2
优先权日:2010-09-14
标题 :Synthesis of new benzothiazole derivatives as potential anti-tubercular agents
发明人:KAMAL AHMED; SHETTI RAJESH VCRNC; SWAPNA PONNAMPALLI; AZEEZA SHAIK; REDDY A MALLA; KHAN INSHAD ALI; ABDULLAH SHEIKH TASDUQ; SHARMA SANDEEP; KALIA NITIN PAL
权利人:COUNCIL SCIENT IND RES
摘要:Disclosed are compounds of general formula A useful as potential anti-tubercular agents. The general formula A is

专利号:US-8034895-B2
优先权日:2004-02-04
标题 :Conjugated thiophenes having conducting properties and synthesis of same
发明人:SKENE WILLIAM G
权利人:UNIV MONTREAL
摘要:The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favor of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.

专利号:US-2008214565-A1
优先权日:2003-04-07
标 题:Oxazolidinone Derivatives as Antimicrobials
发明人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK
权利人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones of formula I and H and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:WO-2004099199-A1
优先权日:2003-05-06
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; RAO AJJARAPU VENKATA SUBRAHMAN; RATTAN ASHOK
权利人:RANBAXY LAB LTD; MEHTA ANITA; RAO AJJARAPU VENKATA SUBRAHMAN; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones of formula (I) or (II) and to the processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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主要参考文献

[参考文献]: Michael P Doyle, Et Al. Asymmetric Hetero-Diels-Alder Reaction Catalyzed By Dirhodium(Ii) Carboxamidates. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5391-5.
[参考文献]: R J Alaimo, Et Al. Antibacterial 2,3-Dihydro-2-(5-Nitro-2-Thienyl)-Quinazolin-4(1H)-Ones. J Med Chem. 1972 Mar;15(3):335-6.

合成参考文献


摘要:Williams, A. C.; Camp, N., Science of Synthesis, (2003) 14, 426.
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