专利号:US-11873315-B2 优先权日:2017-06-16 标 题 :Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts 发明人:KANG JUN YONG; HUANG HAI 权利人:The Board of Regents of the Nevada System of Higher Education on Behalf of the Univ of Nevada; THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE 摘要:Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:WO-2017083719-A1 优先权日:2015-11-13 标 题:Transition metal free methods of synthesis of biaryl compounds 发明人:GAO HONGYIN; KURTI LASZLO 权利人:UNIV RICE WILLIAM M 摘要:The present disclosure provides methods of preparing biaryl compounds which do not require transition metal catalysts. In yet another aspect, the present disclosure provides pharmaceutical compositions comprising compounds as described herein and pharmaceutically acceptable carriers.
专利号:WO-2024126092-A1 优先权日:2022-12-14 标题:Method for producing 5-hmf by converting a syrup in a non-aqueous solvent with extraction of the syrup water upstream of the synthesis 发明人:BOURAS MERIEM; DANG THI BICH NGOC; FERNANDEZ ESPADA PASTOR MARIA; LORCET HÉLÈNE; PAGOT ALEXANDRE; BREUIL PIERRE-ALAIN 权利人:IFP ENERGIES NOW 摘要:The present invention relates to a method for producing a 5-hydroxymethylfurfural (5-HMF) solution, comprising a step a) of bringing a feedstock comprising a hexose into contact with a synthesis solvent and an acid dehydration catalyst, said step being performed at a temperature of between 30 and 200°C, preferably between 50 and 180°C, more preferably between 70 and 150°C and very preferably between 90 and 130°C, and at a pressure of between 0.001 MPa and 10 MPa, preferably between 0.001 MPa and 5 MPa, more preferably between 0.01 MPa and 1 MPa, obtaining a reaction medium and concomitantly extracting the water from the reaction medium, in order to obtain a synthesis effluent comprising 5-HMF and synthesis solvent.
专利号:WO-2025087830-A1 优先权日:2023-10-25 标 题:Production of 5-hmf in a non-aqueous solvent, with concentration of the 5-hmf prior to liquid-liquid extraction 发明人:JACQUIN MARC; PAGOT ALEXANDRE 权利人:IFP ENERGIES NOW 摘要:The invention relates to a process for producing 5-hydroxymethylfurfural (5-HMF), comprising, in succession: a) bringing a sugar feedstock into contact with a polar aprotic synthesis solvent and an acid dehydration catalyst, at a temperature of 30-200°C and a pressure of 0.001-10 MPa, in order to produce a synthesis effluent that includes 5-HMF; b) concentrating the 5-HMF in the synthesis effluent; c) bringing the concentrated synthesis effluent into contact with an aqueous stream; d) liquid-liquid extraction with an organic extraction solvent, followed by a step e) of backwashing with an aqueous solvent in order to obtain an organic raffinate rich in 5-HMF and in solvent. The optionally concentrated organic raffinate is then subjected to a purification step g), for example hydrodistillation or crystallisation, in order to obtain a 5-HMF stream, for example in the form of an aqueous 5-HMF solution or crystalline 5-HMF.
专利号:WO-2024126091-A1 优先权日:2022-12-14 标 题:Method for producing 5-hmf via conversion of sugar in a non-aqueous solvent with water extraction during synthesis 发明人:BOURAS MERIEM; DANG THI BICH NGOC; FERNANDEZ ESPADA PASTOR MARIA; LARMIER KIM; LORCET HÉLÈNE; PAGOT ALEXANDRE 权利人:IFP ENERGIES NOW 摘要:The present invention relates to a method for producing a solution of 5-hydroxymethylfurfural (5-HMF), the method comprising a step a) of bringing a feedstock comprising a hexose into contact with a synthesis solvent and a dehydration acid catalyst, carried out at a temperature of between 30 and 200°C, preferably between 50 and 180°C, more preferably between 70 and 150°C and very preferably between 90 and 130°C, and at a pressure of between 0.001 MPa and 10 MPa, preferably between 0.001 MPa and 5 MPa, and more preferably between 0.01 MPa and 1 MPa, obtaining a reaction medium and concomitantly extracting the water from the reaction medium, to obtain a synthesis effluent comprising 5-HMF and synthesis solvent.
专利号:US-6900340-B2 优先权日:2001-02-02 标 题:Preparation of isocoumarin derivatives and intermediates for the synthesis thereof 发明人:NAKATA MASAYA 权利人:MERCIAN CORP 摘要:A method of preparing optically active isocoumarin-3-yl-acetic acid derivatives represented by Formula (I): n n nwherein a specific isocoumarin-ketene derivative is subjected to an addition reaction with an optically active alcohol, and then the ester thus obtained is subjected to a hydrolysis reaction. An intermediate for synthesis used therein. A method of preparing isocoumarin-3-yl-acetic acid derivatives represented by Formula (III): n n nwherein a specific isocoumarin derivative is subjected to an addition reaction with carbon monoxide and oxygen in the presence of a transition metal catalyst. An intermediate for synthesis used therein.