CAS: 3038-48-0; 2-(Trifluoromethyl)Phenylacetic Acid

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📜N,N-Dimethyl-1-(2-(Trifluoromethyl)Phenyl)Methanamine置于(4,4'-二叔丁基-2,2'-联吡啶)双[(2-吡啶基)苯基]铱(III)六氟磷酸盐,Sodium Carbonate,Caesium Carbonate体系中,用 乙醚,N,N-二甲基甲酰胺 用作溶剂,化学反应 26.0H,反应生成2-(三氟甲基)苯乙酸
参考文献:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
标题:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
摘要:两个亲电子试剂之间的交叉亲电子试剂偶联是在化学计量外部还原剂存在下反应生成Cc 键的有效且经济的方法.在此,我们报告了一种通过可见光光氧化还原催化实现第一个无外部还原剂的交叉亲电子偶联的新策略.各种带有伯,仲和叔 Cn 键的四烷基铵盐与醛/酮和 Co2 进行选择性偶联.值得注意的是,原位生成的副产物三甲胺被有效地用作电子供体.此外,该协议表现出温和的反应条件,低催化剂负载,广泛的底物范围,非常好的官能团耐受性和容易的可扩展性.机理研究表明,苄基自由基和阴离子可能是通过光催化产生的关键中间体,
Doi:10.1021/jacs.8B08792

专利信息

专利号:US-6177572-B1
优先权日:1997-08-20
标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
发明人：WANG FENGJIANG
权利人:SEPRACOR INC
摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

专利号:WO-2023035571-A1
优先权日:2021-09-10
标 题:Synthesis method for esaxerenone and intermediate thereof
发明人：RUAN JING; ZHANG XINXIN; YAN GONGCHAO; RUAN XIAONA; ZHANG WEI
权利人:SHANGHAI DINGYA PHARMACEUTICAL CHEMICALS CO LTD
摘要:Provided is a new synthesis method for an intermediate of esaxerenone. The method comprises: (1) reacting 2-(trifluoromethyl)phenylacetic acid as a raw material with ethyl chloroformate or isobutyl chloroformate in an inert solvent in the presence of an alkali to produce a mixed anhydride, then reacting same with ammonia to obtain a corresponding amide compound of formula II; (2) subjecting the amide compound of formula II obtained in step (1) to a dehydration reaction in the presence of a dehydrating agent and an acid-binding agent to obtain an isocyanide compound of formula III; and (3) subjecting the isocyanide compound of formula III obtained in step (2) to a cyclization reaction with ethyl 2-butynonate in the presence of an alkali and a metal catalyst to form a pyrrole ring compound of formula IV; and the reaction equation is shown below: Compared to the prior art, the technical solution of the present invention has the advantages of a high yield, a simple post-treatment, low costs and easy industrialization, etc.

专利号:US-2011172427-A1
优先权日:2008-08-27
标 题 :Process for preparing certain cinnamide compounds
发明人：NAKAMURA TAIJU; MATSUDA MASAAKI; HU YONGBO; HASEGAWA DAIJU; HOSHINO YORIHISA; INANAGA KAZATO; ISOMURA MINETAKA; SATO NOBUAKI; YOSHIZAWA KAZUHIRO; MONIZ GEORGE A; WILKIE GORDON D; FANG FRANCIS G; NISHIKAWA YOSHIHIRO
权利人:EISAI R&D MAN CO LTD
摘要:This invention relates to a new synthesis, intermediates and precursors leading to a mixture of the compounds 11 and 12 as shown below. It also relates to the resolution of the stereoisomeric mixture to provide in substantial stereochemical purity compound 12. The synthesis of the invention involves preparation of compound 7 and compound 10 as shown below and their reaction to prepare a mixture of compound 11 and compound 12.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:EP-3191464-A1
优先权日:2014-09-10
标题:Synthesis of isoflavanes and intermediates thereof

专利号:WO-2016038061-A1
优先权日:2014-09-10
标题:Synthesis of isoflavanes and intermediates thereof