CAS: 23190-16-1; (1R,2S)-(-)-2-Amino-1,2-Diphenylethanol

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CAS号133522-22-2 (1R,2S)-1,2-dip... | CAS号441-38-3 α-安息香肟 | CAS号52340-78-0 (R,R)-(+)-氢化苯偶姻 | CAS号1439-07-2 反-1,2-二苯基环氧乙烷 | CAS号68331-57-7 erythro-1,2-dip... | CAS号530-36-9 1,2-二苯基-2-氨基乙醇 | CAS号134-81-6 联苯甲酰 | CAS号574-13-0 (E)-2-hydroxy-1... | CAS号5928-66-5 (R)-(-)-苯偶姻 | CAS号111934-06-6 benzyl 3-bromo-... | CAS号943-73-7 L-高苯丙氨酸 | CAS号222555-57-9 (1R,2s)-2-(异丙基氨... | CAS号23204-70-8 (4S,5R)-4,5-二苯基... | CAS号5928-66-5 (R)-(-)-苯偶姻 | CAS号153322-11-3 4-CHLORO-3-NITR... | CAS号100678-82-8 2-((1S,2R)-2-羟基... | CAS号23364-44-5 (1S,2R)-2-氨基-1,... | CAS号100516-54-9 (2R,3S)-N-苄氧羰基-...

(R)-(+)-苯乙醇腈置于咪唑,4-二甲氨基吡啶,Zinc(II) Tetrahydroborate体系中,用 乙醚 用作溶剂,化学反应 1.0H,反应生成(1R,2S)-2-氨基-1,2-二苯基乙醇
参考文献:Applications Of Optically Active Aryl Cyanohydrins In The Synthesis Of α-Hydroxy Aldehydes,α-Hydroxy Ketones And β-Hydroxy Amines
标题:Applications Of Optically Active Aryl Cyanohydrins In The Synthesis Of α-Hydroxy Aldehydes,α-Hydroxy Ketones And β-Hydroxy Amines
摘要:从芳基醛中制备的高光学纯度氰基卤素可转化为 α-羟基醛,β-羟基酮和β-羟基胺,且无任何外消旋化现象,在新引入的立体中心处,赤式二对映异构体通常具有非常好的立体选择性(90%).
Doi:10.1071/ch9902045

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:US-6509506-B1
优先权日:1997-05-21
标 题 :Two step synthesis of D- and L- α-amino acids and D- and L- α-amino aldehydes
发明人：SHARPLESS K BARRY; LI GUIGEN
权利人:SCRIPPS RESEARCH INST
摘要:D- and L- α-amino acids and D- and L-α-amino aldehydes are synthesized from olefin substrates in two steps. The first step is a catalyzed asymmetric aminohydroxylation addition reaction to the olefin substrate. The addition reaction is catalyzed by osmium and is co-catalyzed by chiral ligands. The chiral ligands, in addition to being co-catalysts with the osmium, also serve to direct the addition reaction regioselectively and enantioselectively, divalent ligands are preferred over monovalent ligands because of their enhanced regio-and enantio-selectivity. As an oxidant nitrogen source for the addition reaction, either a carbamate or sulfonamide may be employed. If carbamate is employed as an oxidant nitrogen source, the resultant β-hydoxycarbamate is deprotected to yield the corresponding β-hydroxyamine. If sulfonamide is employed as an oxidant nitrogen source, the resultant β-hydroxysulfonamide is deprotected to yield the corresponding β-hydroxyamine. The resultant β-hydroxyamine is then selectively oxidized in a second synthetic step to produce the desired D- and L- α-amino acid or D- and L-α-amino aldehyde.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.