CAS: 2234-82-4; Propylmagnesium Chloride

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1-氯丙烷置于magnesium,1,2-二溴乙烷体系中,用 甲苯 用作溶剂,化学反应生成丙基氯化镁
参考文献:一种1-丙基磷酸酐的合成方法
标题:一种1-丙基磷酸酐的合成方法
摘要:本发明公开了一种1‑丙基磷酸酐的合成方法,属于化学合成技术领域.本发明以三氯氧磷和丙基氯化镁格式试剂为原料,在甲苯溶剂中,经过取代,水解和脱水环合三步反应,得到1‑丙基磷酸酐.本发明提供的方法制备的1‑丙基磷酸酐的收率>=88%,产品纯度>=98%.此外,本发明提供的方法还具有原材料易得,反映步骤少,反应条件温和,易于工业化放大生产等优点.

专利信息

专利号:US-10000432-B2
优先权日:2014-01-13
标 题 :Processes for the synthesis of chiral 1-alkanols
发明人：NEGISHI EI-ICHI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

专利号:US-4501921-A
优先权日:1982-11-18
标题 :Synthesis of alkylidene intermediates
发明人：RYAN CHARLES W; SLOMSKI BRUCE A
权利人:LILLY CO ELI
摘要:A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-α-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.

专利号:US-2012010409-A1
优先权日:2009-03-19
标题:Improved chemical synthesis of diazaindoles by chichibabin cyclization
发明人：LEE GEORGE E; SHRIMP II FREDERICK L; WEIBERTH FRANZ J
权利人:LEE GEORGE E; SHRIMP II FREDERICK L; WEIBERTH FRANZ J; SANOFI SA
摘要:An improved synthesis method for making diazaindoles using a Chichibabin cyclization is disclosed. In particular, this method is useful for making the compound of Formula I.

专利号:US-6175009-B1
优先权日:1999-11-18
标题:Process for the preparation of quinazolinones
发明人：CONFALONE PASQUALE NICHOLAS; MAGNUS NICHOLAS ANDREW; STORACE LOUIS
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to an asymmetric synthesis of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones, and intermediates thereof. The target compounds are useful for the treatment of human immunodeficiency virus (HIV) as an inhibitor of reverse transcriptase.

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:WO-0029391-A1
优先权日:1998-11-19
标题 :Process for the preparation of quinazolinones
发明人：CONFALONE PASQUALE NICHOLAS; MAGNUS NICHOLAS ANDREW; STORACE LOUIS
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to an asymmetric synthesis of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones, and intermediates thereof. The target compounds are useful for the treatment of human immunodeficiency virus (HIV) as an inhibitor of reverse transcriptase.