CAS: 220227-37-2; (3,4,5-Trifluorophenyl)Methanol

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CAS号220141-72-0 3,4,5-三氟溴苄

📜3,4,5-三氟苯甲醛置于sodium Tetrahydroborate体系中,用 乙醇 用作溶剂,化学反应 0.5H,反应生成3,4,5-三氟苯甲醇
参考文献:溶胶-凝胶二氧化硅玻璃和客体分子之间的意外相互作用.从疏水溶剂中将芳香烃萃取到极性二氧化硅中
标题:溶胶-凝胶二氧化硅玻璃和客体分子之间的意外相互作用.从疏水溶剂中将芳香烃萃取到极性二氧化硅中
摘要:溶质的性质在游离溶液和限制在溶胶-凝胶玻璃孔隙中的溶液之间可能有很大差异.我们研究了溶液中的各种芳香族有机化合物进入浸入该溶液中的溶胶-凝胶二氧化硅整体.溶质的分配通过吸收系数,其在玻璃中和在平衡时周围溶液中的浓度比来量化.该系数对溶剂的依赖性可以深入了解溶质和二氧化硅基质之间可能的相互作用.我们报告了总共 31 种化合物的摄取: 18 种苯的卤素衍生物;5 缩合(稠合)芳烃;和二苯乙烯及其三个取代的衍生物,每个都具有顺式和反式构型.当溶剂为己烷时,吸收系数如下:1.0-1.9 用于卤代苯;烃类为 3.0-4.6;芪类为 3.3-4.9.当溶剂为四氯化碳或二氯甲烷时,吸收系数变为0.8...
Doi:10.1021/jp0021042

专利信息

专利号:US-3876689-A
优先权日:1972-08-28
标题:One-step synthesis of alpha, beta-unsaturated sulfonate salts by the reaction of carbon tetrahalides with certain sulfones
发明人：MEYERS CAL Y; HO LAURENCE L
权利人:UNIV SOUTHERN ILLINOIS
摘要:.alpha.,.beta.-Unsaturated sulfonic acid salts are prepared by a one step synthesis involving reaction of a di-primary alkyl sulfone, an arylmethyl primary alkyl sulfone, an .alpha.-halo diprimary alkyl sulfone, or an .alpha.-haloarylmethyl primary alkyl sulfone with a carbon tetrahalide and a strong base. The sulfone substrate is reacted with a carbon tetrahalide represented by the formula CBr.sub.m Cl.sub.n F.sub.p where m and n are integers between 0 and 4 inclusive, p is an integer between 0 and 2 inclusive and m+n+p = 4 in the presence of the strong base to form a geminally .alpha.-dihalogenated intermediate and dihalocarbene. The geminally .beta.-dihalogenated intermediate reacts rapidly in situ with the strong base to form an .alpha.,.beta.-unsaturated sulfonic acid salt and a halide salt. The unsaturated sulfonic acid salt may be acidified to form the corresponding acid or reacted with a halogenating agent to form the corresponding acid halide. .alpha.,.beta.-Unsaturated sulfonic acid salts are useful detergents.

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.