CAS: 209467-52-7; Ceftobiprole

📜(6R,7R)-7-[(Z)-2-(5-Amino-[1,2,4]Thiadiazol-3-yl)-2-Trityloxyiminoacetylamino]-8-Oxo-3-[(E)-(R)-2-Oxo-[1,3']Bipyrrolidinyl-3-Ylidenemethyl]-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylic Acid 以49的收率获得头孢吡普
参考文献:Derivatives Of 3-(2-Oxo-[1,3']Bipyrrolidinyl-3-Ylidenemethyl)-Cephams
标题:Derivatives Of 3-(2-Oxo-[1,3']Bipyrrolidinyl-3-Ylidenemethyl)-Cephams
摘要:本发明提供了式i的化合物,其中r1为氢,C1-6-烷基,C1-6-烷基取代氟,或c3-6-环烷基;R2为氢或从群组中选择的取代基,该群组包括-ch2C(═chr)-coor,-ch2ocor,-ch(R)ocor,-ch(R)ocoor,-ch(ocor)ocor,-ch2Coch2ocor和r3为氢或从群组中选择的取代基,该群组包括-ch2C(═ch2)-coor,-cooch2C(═chr)-coor,-cooch2ocor,-cooch(R)ocor,-cooch(R)ocoor,-cooch(ocor)ocor,-cooch2Coch2ocor,且其中r2和r3中的一个为氢,另一个不是氢,R为氢或c1-6-烷基;R4为氢或羟基,R5为氢或&ohgr;-羟基烷基;X为ch或n,这些化合物的药学上可接受的盐和它们的盐的水合物.

专利信息

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-10443047-B2
优先权日:2014-05-01
标题 :Increasing cellular lipid production by increasing the activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
发明人：TSAKRAKLIDES VASILIKI; BREVNOVA ELENA E
权利人:NOVOGY INC
摘要:Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.

专利号:US-9006421-B2
优先权日:2013-03-14
标题 :Cephalosporin compositions and methods of manufacture
发明人：LAI JAN-JI; PATHARE PRADIP M; KOLLA LAXMA; SORET ADRIEN F
权利人:CUBIST PHARM INC
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-10065924-B2
优先权日:2014-07-22
标 题 :Preparation and biological evaluation of viridicatumtoxin analogs
发明人：NICOLAOU KYRIACOS C; HALE CHRISTOPHER R H; NILEWSKI CHRISTIAN; IOANNIDOU HERAKLIDIA; EL MARROUNI ABDELLATIF
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:WO-2022221748-A1
优先权日:2021-04-16
标题 :Synthesis of antimicrobial pvp-coated bismuth nanoparticles