CAS: 2025-95-8; 1,8-Bis(Bromomethyl)Naphthalene

相似化合物

58791-49-4 3163-27-7 4542-77-2

上下游产品

naphthalene-1,8-diyldimethanol 1,8-Naphthalic anhydride 1,8-dimethylnaphthalene dimethyl naphthalene-1,8-dicarboxylate 1,8-dimethylnaphthalene acenaphthene 2,3-dihydro-(2-phenylmethyl)-1H-benz[de]isoquinoline -triphenylphosphoniumbromid8-Brommethylnaphthyl-(1)-methyl-triphenylphosphoniumbromid

📜1,8-萘二甲酸二甲酯置于吡啶,Lithium Aluminium Tetrahydride,乙醚,三溴化磷,苯体系中,化学反应生成1,8-双(溴甲基)萘
参考文献:A New Synthesis Of Acenaphthene
标题:A New Synthesis Of Acenaphthene
摘要:
Doi:10.1021/ja01107A501

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-5856492-A
优先权日:1997-01-10
标题 :Efficient synthesis of a chiral mediator
发明人：CHEN CHENG YI; XU FENG; TILLYER RICHARD D; ZHAO DALIAN
权利人:MERCK & CO INC
摘要:An efficient method for the quantitative preparation and isolation of a compound of formula I ##STR1## or its enantiomer, a chiral mediator used in enantioselective synthesis.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-5665827-A
优先权日:1996-11-07
标 题:Synthesis of multiblock polymers using group IIA and IIB metal cyclic organometallic initiators
发明人：HALL JAMES E
权利人:BRIDGESTONE CORP
摘要:The invention is a practical process for anionically synthesizing multiblock polymers containing a plurality of blocks formed from polar and/or non-polar monomers by using a cyclic organometallic compound initiator that comprises a divalent metal atom and an organic moiety contained in a ring, preferably a cycloorganomagnesium initiator. Activation of the ring metallic atom results in anionic polymerization of the monomers by addition into the initiator ring at the bonds between the metallic atom and its two adjacent carbon atoms, the metallic atom acting as a bridge between the two living ends of the propagating chain. The active chain ends can be coupled or terminated.