其它别名Basic Blue 24; C.I. Basic Blue 24; New Methylene Blue; Phenothiazin-5-Ium,7-Bis(Ethylamino)-2,8-Dimethyl-, Chloride; Ethyl-[7-(Ethylamino)-2,8-Dimethylphenothiazin-3-Ylidene]Azanium; Ch
专利号:US-2003131363-A1 优先权日:2001-12-07 标 题 :Heme-regulated eukaryotic initiation factor 2 alpha kinase knockout mice and methods for use 发明人:CHEN JANE-JANE 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The targeted disruption of the gene encoding the heme-regulated eIF2-kinase (HRI) in mice establishes that HRI, which is expressed predominantly in erythroid cells, regulates the synthesis of both alpha and beta globins in red blood cell precursors by inhibiting the general translation initiation factor eIF2. HRI is a physiological regulator of gene expression in the erythroid lineage and acts both as a sensor of heme and an effector controlling the initiation of translation. Accordingly regulation of HRI can be used to control proliferation of cells, especially cells of hematopoietic origin, using compositions and compounds identified using HRI deficient mice.
专利号:US-2016144002-A1 优先权日:1999-08-30 标题:Sickled Erythrocytes and Progenitors Target Cytotoxics to Tumors 发明人:TERMAN DAVID S 权利人:TERMAN DAVID S 摘要:The present invention provides therapeutic mammalian cells which synthesize and express SS hemoglobin and a tumoricidal transgene. They are produced by transduction of SS erythroid progenitors/erythroblasts using viral vectors comprising a tumoricidal transgene operatively linked to the coding region of SS β-globin promoter/enhancer. Such transduced SS erythroid cells differentiate into mature SSRBCs that exhibit sustained synthesis and expression of SS hemoglobin, a tumoricidal protein(s). Both mature and progenitor SS-cells carrying tumoricidal transgene(s) are capable of selectively localizing in tumor microenvironment, occluding tumor microvessels and inducing a tumoricidal response.
专利号:CN-107983385-A 优先权日:2017-11-28 标 题:A kind of nickel base magnetic composite material and its synthesis method and application
专利号:CN-107983385-B 优先权日:2017-11-28 标题:A kind of nickel-based magnetic composite material and its synthesis method and application