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专利信息
专利号:US-8563763-B2
优先权日:2011-04-05
标 题 :Composition, synthesis and use of isonitriles
发明人:FLEMING FRASER FERGUSON; PITTA BHASKAR REDDY
权利人:FLEMING FRASER FERGUSON; PITTA BHASKAR REDDY; UNIV HOLY GHOST DUQUESNE
摘要:The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
专利号:US-2012108828-A1
优先权日:2010-09-09
标题 :Synthesis of dronedarone and salts thereof
发明人:SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR
权利人:SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR; USV LTD B S D MARG
摘要:The present invention relates to a process for preparation of Dronedarone or pharmaceutically acceptable salts thereof. More particularly, the present invention provides a process for preparation of Dronedarone hydrochloride, without the isolation of Dronedarone base.
专利号:US-5891995-A
优先权日:1991-04-12
标 题 :Substituted benzhydrylamines as handles for solid phase peptide synthesis
发明人:LEBL MICHAL; PATEK MARCEL
摘要:The present invention is directed to a novel 'handle' for solid phase peptide synthesis. The handles can be converted from a stable form to a labile form, allowing for cleavage of a peptide amide from the support after synthesis under mild conditions, and after deprotection of the amino acid side chains. The handles are based on a substituted benzhydrylamine skeleton.
专利号:US-11702430-B2
优先权日:2018-04-03
标 题:Aza-benzothiophene compounds as STING agonists
发明人:ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
权利人:MERCK SHARP & DOHME LLC; ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
摘要:Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , R 9 , A, X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.
专利号:EP-2428511-A1
优先权日:2010-09-09
标 题:Synthesis of dronedarone and salts thereof
专利号:HU-222239-B1
优先权日:1991-04-12
标 题 :Process for the Preparation of Substituted Benzhydrylamine Linking Compounds for Solid Phase Peptide Synthesis and Conjugates Containing Them, and Peptide Synthesis with them.