CAS: 171856-09-0; 2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)(4-((Tert-Butoxycarbonyl)Amino)Butyl)Amino)Acetic Acid

该化合物是一种受保护的氨基酸衍生物,广泛用于peptide合成,该化合物的特点是N-终点的Fmoc(9-氟烯基甲基碳基)组,为固相peptide合成(SPPS)提供合适的正方位保护;氨基丁基边链上的Boc(乙氧碳基)组确保在酸性条件下有选择地减少保护,使peptide链能够相继延长;这一衍生物对于在Peptide设计中引入带有空间臂的晶体残留物,便利将功能处理器或分支结构纳入peptited设计特别宝贵;在标准SPPS条件下,其高纯度和稳定性使它成为复杂的peptide和peptiometic应用的可靠建筑块.

英文名称2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)(4-((Tert-Butoxycarbonyl)Amino)Butyl)Amino)Acetic Acid
中文名称Fmoc-N-(4-Boc-氨丁基)-Gly-OH
IUPAC名称N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(4-((tert-butoxycarbonyl)amino)butyl)glycine
其它别名Fmoc-N-(4-Boc-Aminobutyl)-Glycine; Fmoc-N-(4-Boc-Aminobutyl)-Gly-Oh; Fmoc-Nlys(Boc)-Oh; Fmoc-N-(4-Boc-Aminobutyl)Glycine, Fmoc-Nlys(Boc)-Oh; [[4-[(Tert-Butoxycarbonyl)Amino]Butyl](9H-Fluoren-9-Ylmethoxycarbonyl)Amino]Acetic Acid; N-[4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]Butyl]-N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Glycine; N-Fmoc-N-(4-Boc-Aminobutyl)Glycine; Fmoc-Abg(Boc)-Oh
CAS编号171856-09-0
MFCD编号:MFCD04112689
EINECS号:633-990-3
分子式:C26H32N2O6分子量:468.55
产品CID: 881404
产品分类生物化工 → 氨基酸及其衍生物 → 甘氨酸类衍生物

相似结构搜索
InChIKey: MNAXPVXIHALBEF-UHFFFAOYSA-N
InChI=1S/C26H32N2O6/c1-26(2,3)34-24(31)27-14-8-9-15-28(16-23(29)30)25(32)33-17-22-20-12-6-4-10-18(20)19-11-5-7-13-21(19)22/h4-7,10-13,22H,8-9,14-17H2,1-3H3,(H,27,31)(H,29
计算化学: 氢键受体数6.0氢键供体数2.0可旋转键数12.0

MSDS等安全信息

GHS象形图
GHS符号GHS09;
注释: Environment
危险类别水生急性毒性类别1
水生慢性毒性类别1
警示词Warning(警告)
危险描述H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
防范说明P273-P501
UN编号UN 3077 9/PG 3
危险品标志N
安全声明60-61
危险类别码50/53
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

📜Tert-Butyl 4-(Benzylamino)Butylcarbamate置于palladium On Activated Charcoal 氢气,三乙胺,N,N-二异丙基乙胺体系中,用甲醇,N,N-二甲基甲酰胺,乙腈用作溶剂,25.0 °C,413.69 Kpa 条件下,反应 11.5H,反应生成Fmoc-N-(4-Boc-氨丁基)-Gly-Oh
参考文献:Building Units For N-Backbone Cyclic Peptides. 3. Synthesis Of Protected Nα-(ω-Aminoalkyl)Amino Acids And Nα-(ω-Carboxyalkyl)Amino Acids
标题:Building Units For N-Backbone Cyclic Peptides. 3. Synthesis Of Protected Nα-(ω-Aminoalkyl)Amino Acids And Nα-(ω-Carboxyalkyl)Amino Acids
摘要:An Improved Synthesis Of A Family Of Amino Acids That Contain Omega-Aminoalkyl Groups And Of A New Family Containing Omega-Carboxyalkyl Groups Linked To The Alpha-Amine Is Described. The Synthesis Was Performed By Alkylation Of Suitably Monoprotected Alkylenediamines And Protected Omega-Amino Acids With Triflates Of Alpha-Hydroxy Acid Esters. The Reaction Proceeded With Inversion Of Configuration Yielding Optically Pure Products. The N-Alpha-(Omega-Aminoalkyl)Amino Acids And N-Alpha-(Omega-Carboxyalkyl)Amino Acids Were Orthogonally Protected To Allow Their Incorporation Into Peptides By Solid-Phase Peptide Synthesis (Spps) Methodology.
Doi:10.1021/jo961580E