CAS: 16251-77-7; 3-Phenylbutyraldehyde

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4593-90-2 772-14-5 6325-41-3

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1-bromo-2-phenylpropane 3-phenyl-1-butanol 1,1,1-trichloro-4-phenyl-pentan-2-ol (E)-but-2-enol 2-Formylamino-4-phenyl-pentanoic acid amide methyl hexanoate 2-chloro-3-phenylbutyraldehyde dimethyl acetal (4S,5S)-1,3-Dimethyl-4,5-diphenyl-2-(2-phenyl-propyl)-imidazolidine

📜(+/-)-3-苯基丁酸置于二异丁基氢化铝,戴斯-马丁氧化剂体系中,用 乙醚,二氯甲烷 用作溶剂,化学反应 2.5H,反应生成3-苯基丁醛
参考文献:探索合成有用的丝氨酸蛋白酶使用手性醛抑制剂区分远程立体中心构型的能力
标题:探索合成有用的丝氨酸蛋白酶使用手性醛抑制剂区分远程立体中心构型的能力
摘要:已经使用手性醛过渡态类似物抑制剂作为探针探索了合成有用的丝氨酸蛋白酶,枯草杆菌蛋白酶 (Sc) 和 α-胰凝乳蛋白酶 (Ct) 区分远离催化位点的立体中心的 R-和 S-构型的能力. 评估的抑制剂是 (R)-和 (S)-3-苯基丁醛和 (R)-和 (S)-4-苯基戊醛,其中 C-3 和 C-4 的立体中心分别远离醛官能团,与催化丝氨酸残基相互作用.还分别评估了非手性母体化合物 3-苯基丙醛和 4-苯基丁醛以供参考.发现每种醛都是两种酶的竞争性抑制剂,Ct 的抑制效果明显强于 Sc.在这个系列中,与非手性亲本醛相比,R 中心甲基的存在显着改善了两种酶的结合.相比之下,对s-甲基取代基结合的影响相同...
Doi:10.1021/ja952835T

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:EP-0706089-A3
优先权日:1994-10-05
标 题 :Process for the synthesis of a quinonediazide ester and positive working photoresist containing it

专利号:JP-6423972-B2
优先权日:2012-10-05
标题 :Process for the synthesis of cyclohexenone and its use in perfumery production

专利号:US-5723642-A
优先权日:1995-05-12
标题 :Optically activate phosphines,their preparation and their metal complexes, and use in asymmetric synthesis
发明人：STUERMER RAINER; LAUPICHLER LOTHAR; KNOCHEL PAUL; LANGER FALK
权利人:BASF AG
摘要:Optically active phosphines of the general formula I or II ##STR1## where the variables have the following meanings: X is an optically active terpene radical, n R is an unsubstituted or substituted phenyl radical, n Y is a bridge member having 1-10 C atoms in the formula I n n is 1,2 or 3 and n m is 0,1 or 2 with the proviso that n+m=3 in the formula II n n is 1 or 2 and n m is 0 or 1 with the proviso that n+m=2, their preparation and use are described.

专利号:CN-1242007-A
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds