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Trimethyl borate 4-bromo-4'-fluorobiphenyl 硼酸三甲酯,4-溴-4'-氟联苯置于叔丁基锂体系中,用 四氢呋喃 用作溶剂,以93%的收率获得4-(4-氟苯基)苯硼酸
参考文献: Inhibitors Of Notch Signalling Pathway And Use Thereof In Treatment Of Cancers[fr] Inhibiteurs De La Voie De Signalisation Notch Et Leur Utilisation Dans Le Traitement De Cancers
标题: Inhibitors Of Notch Signalling Pathway And Use Thereof In Treatment Of Cancers[fr] Inhibiteurs De La Voie De Signalisation Notch Et Leur Utilisation Dans Le Traitement De Cancers
摘要:本发明涉及新的notch信号通路抑制剂及其在治疗和/或预防癌症中的应用.
专利信息
专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:US-11491263-B2
优先权日:2017-06-01
标 题:Controllable ion release calcium particles, method for producing same and use thereof
发明人:ENGEL LOPEZ ELISABETH; CASTANO LINARES OSCAR; MARTI MUNOZ JOAN; PLANELL ESTANY JOSEP ANTON
权利人:FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA IBEC; UNIV CATALUNYA POLITECNICA
摘要:The present invention refers to a method for the synthesis of a biodegradable calcium release material that shows controlled ion release properties for tissue engineering, biomaterials containing the calcium particles as well as the calcium particles obtainable therefrom. By varying the treatment temperature of the described method, the calcium material shows different calcium release profiles. Contrary to a specific chemical composition such as CaCO 3 which is associated to a specific calcium release profile, the present invention allows a manifold of compositions, with a manifold of calcium release profiles, all starting from a single specific chemical composition calcium precursor. Therefore, the invention also relates to the use of the controllable release, calcium material in tissue regeneration such as wound healing processes.
专利号:DE-69917914-T2
优先权日:1998-09-18
标题 :PRODUCTION OF COMBINATIONAL ARRAYS OF MATERIALS BY METHODS OF SYNTHESIS IN SOLUTION