CAS: 140369-67-1; 4-(4-Fluorophenyl)Phenylboronic Acid

该化合物是一种有机体化合物,其特征是联苯结构中存在一个含有碱酸性功能组,其中一个苯环被氟原子取代,该化合物一般是白色至白外固体,可溶于极有机溶剂,其分子结构允许在药用化学中潜在应用,特别是在药品开发中,因为溴酸可以参与可逆的共价结合二醇,使其在药物设计和交付系统中有用.氟酸原子的存在可以加强该化合物的生物活动和脂质.此外,4-(4-氟联苯)苯乙酸可以作为有机合成的关键中间体,用于交叉组合反应,例如铃木-米亚乌拉联动,这对构建复杂的有机分子至关重要.其再活动性和功能特性使它在研究和工业应用中成为有价值的化合物.

结构式图片

相似化合物

1359844-10-2 409108-13-0 5122-94-1

上下游产品

Trimethyl borate 4-bromo-4'-fluorobiphenyl

合成工艺路线路线简述

    硼酸三甲酯,4-溴-4'-氟联苯置于叔丁基锂体系中,用 四氢呋喃 用作溶剂,以93%的收率获得4-(4-氟苯基)苯硼酸
    参考文献: Inhibitors Of Notch Signalling Pathway And Use Thereof In Treatment Of Cancers[fr] Inhibiteurs De La Voie De Signalisation Notch Et Leur Utilisation Dans Le Traitement De Cancers
    标题: Inhibitors Of Notch Signalling Pathway And Use Thereof In Treatment Of Cancers[fr] Inhibiteurs De La Voie De Signalisation Notch Et Leur Utilisation Dans Le Traitement De Cancers
    摘要:本发明涉及新的notch信号通路抑制剂及其在治疗和/或预防癌症中的应用.

    专利信息


    专利号:US-11225655-B2
    优先权日:2010-04-16
    标题:Bi-functional complexes and methods for making and using such complexes
    发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
    权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
    摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

    专利号:US-11491263-B2
    优先权日:2017-06-01
    标 题:Controllable ion release calcium particles, method for producing same and use thereof
    发明人:ENGEL LOPEZ ELISABETH; CASTANO LINARES OSCAR; MARTI MUNOZ JOAN; PLANELL ESTANY JOSEP ANTON
    权利人:FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA IBEC; UNIV CATALUNYA POLITECNICA
    摘要:The present invention refers to a method for the synthesis of a biodegradable calcium release material that shows controlled ion release properties for tissue engineering, biomaterials containing the calcium particles as well as the calcium particles obtainable therefrom. By varying the treatment temperature of the described method, the calcium material shows different calcium release profiles. Contrary to a specific chemical composition such as CaCO 3 which is associated to a specific calcium release profile, the present invention allows a manifold of compositions, with a manifold of calcium release profiles, all starting from a single specific chemical composition calcium precursor. Therefore, the invention also relates to the use of the controllable release, calcium material in tissue regeneration such as wound healing processes.

    专利号:DE-69917914-T2
    优先权日:1998-09-18
    标题 :PRODUCTION OF COMBINATIONAL ARRAYS OF MATERIALS BY METHODS OF SYNTHESIS IN SOLUTION
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