CAS: 13411-16-0; (6-(2-(5-Nitrofuran-2-yl)Vinyl)Pyridin-2-yl)Methanol

该化合物是一种合成硝化铀衍生物,主要以其抗微生物特性而闻名,其特征是针对各种细菌和原生动物的广泛频谱活动,使其在兽医学中有用,特别是用于治疗牲畜感染;该化合物的特点是附于松鼠环上的硝化物组,该环有助于其生物活动;Nifurpirinol的施用通常以粉末或溶液的形式进行,以其在治疗剂量中的毒性相对较低而闻名;其行动机制包括抑制微生物中的核酸合成,导致其死亡;此外,Nifurpirinnol已就其在人类医学中的潜在用途进行了研究,尽管其主要用途仍在兽医环境中;与许多药品一样,Nfurpirinnol的安全和功效须接受监管审查,其使用应以兽医处方为指导,以避免抗药发展并确保适当剂量.

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    专利信息


    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: Tamse CT, Gacutan RQ, Tamse AF. Changes induced in the gills of milkfish (Chanos chanos Forsskål) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138). Bull Environ Contam Toxicol. 1995 Apr;54(4):591-6. doi: 10.1111/wrr.12633. Epub 2018 May 19. doi: 10.1016/j.aca.2014.12.036. Epub 2014 Dec 24. Epub 2005 Nov 9. Spanish.

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    摘要:Canadian Patents., #919595
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