CAS: 886365-88-4; 5-Bromo-N-Phenylpyrimidin-2-Amine
该化合物是一种含有苯氨基替代成分的溴化火水化合物衍生物,在2点具有苯氨基替代成分,该化合物是有机合成和制药研究的多用途中间体,特别是在发展活性酶抑制剂和其他生物活性分子方面.5点的溴原子可增强反应性,通过Suzuki或Buchwald-Hartwig等交叉反应进一步发挥作用.其稳定的晶体形式确保了处理和储存的便利.苯氨基氨基化合物组有助于其作为设计具有定制约束特性的化合物的剑匠的潜力.这一产品适合于寻求建立高纯度医学或材料科学应用建筑的研究人员.
- 英文名称5-Bromo-N-Phenylpyrimidin-2-Amine
- 中文名称5-溴-N-苯基嘧啶-2-胺
- IUPAC名称5-bromo-N-phenylpyrimidin-2-amine
- 其它别名(5-溴嘧啶-2-基)苯胺; (5-Bromo-Pyrimidin-2-yl)-Phenyl-Amine
- CAS编号886365-88-4
- MFCD编号:MFCD03646013
- 分子式:C10H8BrN3分子量:250.1
- 产品CID: 1902008
- 产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物
相似化合物
57356-49-7 198711-26-1 1289210-04-3物理性质
MSDS等安全信息
上下游产品
5-Bromo-2-chloropyrimidine aniline 2-(phenylamino)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrimidine 5-(4-(benzyloxy)-3-fluorophenyl)-N-phenylpyrimidin-2-amine 1-acetyl-3-(5-bromo-pyrimidin-2-yl)-1-tert-butyl-3-phenyl-urea N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-2-(phenylamino)pyrimidine-5-carboxamide合成工艺路线路线简述
- 合成目标产物 (5-Bromo-Pyrimidin-2-yl)-Phenyl-Amine 主要起始原料 5-Bromo-2-Chloropyrimidine And Aniline
- 32779-36-5 = 886365-88-4
反应条件:1.1 Solvents: 1-Butanol; 21 H,110 °C
标题:Hypervalent Iodine(Iii)-Promoted Direct Synthesis Of Imidazo[1,2-A]Pyrimidines
作者:Qian,Guangyin; Liu,Bingxin; Tan,Qitao; Zhang,Siwen; Xu,Bin
参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(22) 页码:4837-4843]
32779-36-5 = 886365-88-4
反应条件:1.1 Reagents: Acetic Acid Solvents: 1,4-Dioxane; 24 H,110 °C
标题:Rhodium-Catalyzed C-H Carboxymethylation Of Anilines With Vinylene Carbonate
作者:Liu,Qiong; Ma,Zhaolong; Zhang,Jing; Li,Xu-Qin
参考文献:Organic & Biomolecular Chemistry 日期:2023 卷标:21(41) 页码:8320-8328]
591-50-4 + 7752-82-1 = 886365-88-4
反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Cuprous Iodide Solvents: Dimethyl Sulfoxide; 8 H,90 °C
标题:A Simple And Efficient Ligand-Free Copper-Catalyzed C-N Bond Formation Of Aryl (Hetero) Halides And N-Heteroaryl Amines
作者:Kommuri,Venkata Chandrasekhar; Tadiparthi,Krishnaji; Pawar,Lokesh; Arunachalampillai,Athimoolam
参考文献:Polycyclic Aromatic Compounds 日期:2023 卷标:43(1) 页码:665-673]
32779-36-5 = 886365-88-4
反应条件:1.1 Reagents: Acetic Acid Solvents: 1,4-Dioxane; 8 - 24 H,110 °C
标题:Catalyst-Controlled Chemodivergent Reactivity Of Vinyl Cyclopropanes: A Selective Approach Toward Indoles And Aniline Derivatives
作者:Keshri,Santosh Kumar; Madhavan,Suchithra; Kapur,Manmohan
参考文献:Organic Letters 日期:2022 卷标:24(49) 页码:9043-9048]
32779-36-5 = 886365-88-4
反应条件:1.1 Solvents: 1-Butanol; 21 H,110 °C
标题:A Copper-Mediated Tandem Reaction Through Isocyanide Insertion Into N-H Bonds: Efficient Access To Unsymmetrical Tetrasubstituted Ureas
作者:Huang,Xiaomei; Xu,Shuguang; Tan,Qitao; Gao,Mingchun; Li,Minjie; Et Al
参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(12) 页码:1465-1468]
32779-36-5 = 886365-88-4
反应条件:1.1 Solvents: Acetic Acid,1,4-Dioxane; 24 H,110 °C
标题:A Novel Approach To α-Arylacetonitrile Skeletons Via Para-Selective Alkylation Of Protected Anilines
作者:Deng,Zefeng; Fan,Weitai; Liu,Jian; Tu,Guangliang; Huang,Pengcheng; Et Al
参考文献:Chemistry - A European Journal 日期:2023 卷标:29(44)
📜5-溴-2-氯嘧啶,苯胺置于溶剂黄146体系中,用 正丁醇 作为反应溶剂,化学反应 21.0H,以56%的收率获得产物(5-溴嘧啶-2-基)苯胺
参考文献:A Copper-Mediated Tandem Reaction Through Isocyanide Insertion Into N-h Bonds: Efficient Access To Unsymmetrical Tetrasubstituted Ureas
标题:A Copper-Mediated Tandem Reaction Through Isocyanide Insertion Into N-h Bonds: Efficient Access To Unsymmetrical Tetrasubstituted Ureas
摘要:通过对较不活跃的次级芳香胺的n-H键进行异氰酸酯插入,开发了一种铜介导的多组分反应.这种方法可以在一个锅中高效合成非对称四取代脲.
DOI:10.1039/c3Cc47590E
