CAS: 878-00-2; 4-Acetoxybenzaldehyde

该化合物是一种合成芳香甲酰胺衍生物,其特点是在苯并二烯环的副位置上有一个乙氧功能组,该化合物主要用作有机合成的中间体,特别是在生产药品,农用化学品和特殊化学品方面;其乙氧基组增强反应性,允许在受控制条件下有选择地进行修改;复合物在标准处理条件下具有稳定性,在普通有机溶剂中可溶解,便于在各种反应计划中使用;其明确界定的结构和一贯纯度使其成为复杂的分子框架的可靠建筑块,特别是在药用化学和材料科学应用方面.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号75-36-5 乙酰氯 | CAS号7143-16-0 Methanediol,1-[... | CAS号155164-63-9 2-乙酰基-4,5-二氯-3(... | CAS号108-24-7 乙酸酐 | CAS号150372-43-3 acetic acid,4-(... | CAS号6309-46-2 4-乙酰氧基苯甲醇 | CAS号79721-01-0 4-(dimethoxymet... | CAS号2628-16-2 对乙酰氧基苯乙烯 | CAS号32604-29-8 4,4'-二乙酰氧基联苯 | CAS号6290-82-0 [4-(4-acetyloxy... | CAS号51094-17-8 5,10,15,20-四(4-... | CAS号150372-43-3 acetic acid,4-(... | CAS号14383-55-2 O-Acetyltyramin... | CAS号51-67-2 酪胺 | CAS号4525-75-1 乙酸2-氯苯酯 | CAS号18984-24-2 [4-(2-nitroethe... | CAS号19220-93-0 乙酸五氟苯酯

合成工艺路线路线简述

  • 123-08-0 = 878-00-2
    反应条件:1.1 Reagents: Pyridine,Alumina
    标题:Ac2O-Py/basic Alumina As A Versatile Reagent For Acetylations In Solvent-Free Conditions Under Microwave Irradiation
    作者:Paul,Satya; Et Al
    参考文献:Tetrahedron Letters 日期:2002 卷标:43(23) 页码:4261-4265]

    123-08-0 = 878-00-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C; 0 °C -> Rt; 3 H,Rt
    标题:Formulating A New Basis For The Treatment Against Botulinum Neurotoxin Intoxication: 3,4-Diaminopyridine Prodrug Design And Characterization
    作者:Zakhari,Joseph S.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(21) 页码:6203-6209]

    123-08-0 + 155164-63-9 = 878-00-2
    反应条件:1.1 5 Min,Rt -> 100 °C
    标题:Rapid And Ecofriendly Esterification Of Alcohols With 2-Acylpyridazinones
    作者:Kim,Bo Ram; Et Al
    参考文献:Bulletin Of The Korean Chemical Society 日期:2013 卷标:34(11) 页码:3410-3414]

    123-08-0 + 155164-63-9 = 878-00-2
    反应条件:1.1 Rt; 5 Min,150 °C; Cooled
    标题:Catalyst-Free Esterification Of Alcohols Using 2-Acyl-4,5-Dichloropyridazinones Under Microwave Conditions
    作者:Kim,Bo Ram; Et Al
    参考文献:Tetrahedron 日期:2013 卷标:69(15) 页码:3234-3237]

    150372-43-3 = 878-00-2
    反应条件:1.1 Reagents: Water,Oxygen Catalysts: Bismuth Nitrate Solvents: Benzene1.2 Reagents: Water
    标题:A Catalytic Deprotection Of S,S- S,O- And O,O-Acetals Using Bi(No3)3.5 H2O Under Air
    作者:Komatsu,Naoki; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2001 卷标:343(5) 页码:473-480]

    7143-16-0 = 878-00-2
    反应条件:1.1 Reagents: N,N′-1,2-Ethanediylbis[n-Bromo-4-Methylbenzenesulfonamide] Catalysts: Water; 1.5 Min,Rt
    标题:Solid-State Conversion Of 1,1-Diacetates With N,N'-Dibromo-N,N'-1,2-Ethanediylbis(P-Toluenesulfonamide) To Aldehydes
    作者:Ghorbani-Vaghei,Ramin; Et Al
    参考文献:Mendeleev Communications 日期:2006 卷标:(1) 页码:55-56]

    7143-16-0 = 878-00-2
    反应条件:1.1 Catalysts: Alumina
    标题:Alumina-Mediated Deacetylation Of Benzaldehyde Diacetates. A Simple Deprotection Method
    作者:Varma,Rajender S.; Et Al
    参考文献:Tetrahedron Letters 日期:1993 卷标:34(20) 页码:3207-10]

    465512-95-2 = 878-00-2
    反应条件:1.1 Catalysts: Eosin Solvents: Acetonitrile; 3 H,Rt
    标题:Visible Light Photoredox Catalyzed Deprotection Of 1,3-Oxathiolanes
    作者:Yang,Mingyang; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2020 卷标:18(2) 页码:288-291]

    465512-95-2 = 878-00-2
    反应条件:1.1 Reagents: Sodium Iodide,Cerium Trichloride Solvents: Acetonitrile
    标题:Cecl3.7H2O-Promoted Highly Chemoselective Hydrolysis Of 1,3-Oxathio- And Dithioacetals
    作者:Yadav,J. S.; Et Al
    参考文献:Tetrahedron Letters 日期:2002 卷标:43(26) 页码:4679-4681]

    195054-29-6 = 878-00-2 [标题:Reaction Conditions
    标题:Deprotection Of S,S-Acetals
    作者:Firouzabadi,H.; Et Al
    参考文献:Science Of Synthesis 日期:2007 卷标:30 页码:505-586]

    329930-44-1 = 878-00-2
    反应条件:1.1 Reagents: Trifluoromethanesulfonic Anhydride,2-Fluoropyridine Solvents: Dichloromethane; 0 °C; 20 Min,0 °C1.2 Reagents: 1,1,3,3-Tetramethyldisiloxane; 0 °C; 10 Min,0 °C; 0 °C -> Rt; 6 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 1 - 2 H,Rt1.4 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Tf2O-Tmds Combination For The Direct Reductive Transformation Of Secondary Amides To Aldimines,Aldehydes,And/or Amines
    作者:Lang,Qi-Wei; Et Al
    参考文献:Science China: Chemistry 日期:2016 卷标:59(12) 页码:1638-1644]

    79721-01-0 = 878-00-2
    反应条件:1.1 Catalysts: β-Cyclodextrin Solvents: Water; 50 °C; 12 H,50 °C
    标题:Highly Efficient Deprotection Of Aromatic Acetals Under Neutral Conditions Using β-Cyclodextrin In Water
    作者:Krishnaveni,N. Srilakshmi; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(5) 页码:2018-2019]

    629-11-8 + 1927-95-3 = 878-00-2
    反应条件:1.1 Reagents: Lithium Chloride Catalysts: Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Diiridium,Binap Solvents: Mesitylene,Water; 170 °C1.2 Reagents: N,N,N′,N′-Tetramethylethylenediamine Catalysts: Palladium Diacetate,Catacxium A Solvents: Toluene; 64 H,80 °C
    标题:Hydroformylation Of Olefins And Reductive Carbonylation Of Aryl Halides With Syngas Formed Ex Situ From Dehydrogenative Decarbonylation Of Hexane-1,6-Diol
    作者:Christensen,Stig Holden; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2015 卷标:13(3) 页码:938-945]

    = 878-00-2 [标题:Reaction Conditions
    标题:Catalytic Oxidation Of Alkylphenols To Hydroxybenzoic Acids
    参考文献:Japan]

    123-08-0 = 878-00-2
    反应条件:1.1 Solvents: Pyridine; Rt; 16 H,Rt1.2 Reagents: Sulfuric Acid Solvents: Water; Rt
    标题:Mechanism Of Iodine(Iii)-Promoted Oxidative Dearomatizing Hydroxylation Of Phenols: Evidence For A Radical-Chain Pathway
    作者:Kraszewski,Karol; Et Al
    参考文献:Chemistry - A European Journal 日期:2020 卷标:26(50) 页码:11584-11592]

    123-08-0 = 878-00-2
    反应条件:1.1 Solvents: Pyridine; Rt; 16 H,Rt1.2 Reagents: Isopropyltriphenylphosphonium Bromide Solvents: 4-(4-Penten-1-Yl)Phenol; Rt
    标题:Mechanism Of Iodine(Iii)-Promoted Oxidative Dearomatizing Hydroxylation Of Phenols: Evidence For Radical-Chain Pathway
    作者:Kraszewski,Karol; Et Al
    参考文献:Chemrxiv 日期:2020 卷标:1 页码:1-10]

    123-08-0 = 878-00-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Ethyl Acetate; 5 H,Rt
    标题:Friedel-Crafts Reaction Of Benzyl Fluorides: Selective Activation Of C-F Bonds As Enabled By Hydrogen Bonding
    作者:Champagne,Pier Alexandre; Et Al
    参考文献:Angewandte Chemie 日期:2014 卷标:53(50) 页码:13835-13839]

    123-08-0 = 878-00-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 30 Min,0 °C
    标题:Scope And Limitations Of The Heck-Matsuda-Coupling Of Phenol Diazonium Salts And Styrenes: A Protecting-Group Economic Synthesis Of Phenolic Stilbenes
    作者:Schmidt,Bernd; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2013 卷标:11(22) 页码:3674-3691]

    2628-16-2 = 878-00-2
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Catalysts: Ceria,Iron Oxide (Fe3O4),Iron,Silver Solvents: Acetonitrile; 6 H,80 °C
    标题:Design And Synthesis Of Silver Decorated Fe3O4 @ Fe Doped Ceo2 Core-Shell Ternary Composite As Highly Efficient Nanocatalyst For Selective Oxidation Of Alkenes
    作者:Ghosh,Topi; Et Al
    参考文献:Chemistryselect 日期:2020 卷标:5(31) 页码:9601-9606]

    2628-16-2 = 878-00-2
    反应条件:1.1 Reagents: Sudan Red 7B,Oxygen,Ozone Solvents: Acetone,Water; 0 °C
    标题:Ozonolysis In Solvent/water Mixtures: Direct Conversion Of Alkenes To Aldehydes And Ketones
    作者:Schiaffo,Charles E.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(12) 页码:4688-4690]

    2628-16-2 = 878-00-2
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Vanadium Oxide (V2O5) (Supported On Tio2) Solvents: Acetonitrile; 4 H,30 °C
    标题:V2O5@tio2 Catalyzed Green And Selective Oxidation Of Alcohols,Alkylbenzenes And Styrenes To Carbonyls
    作者:Upadhyay,Rahul; Et Al
    参考文献:Chemcatchem 日期:2021 卷标:13(16) 页码:3594-3600]

    123-08-0 + 155164-63-9 = 878-00-2
    反应条件:1.1 Catalysts: Aluminum Chloride Solvents: Tetrahydrofuran; 1 Min,Rt1.2 30 Min,Rt1.3 Reagents: Water; 10 Min,Rt
    标题:Facile Esterification Of Alcohols With 2-Acyl-4,5-Dichloropyridazin-3(2H)-Ones Under Friedel-Crafts Conditions
    作者:Kim,Bo Ram; Et Al
    参考文献:Synlett 日期:2014 卷标:25(13) 页码:1909-1915]

    150372-43-3 = 878-00-2
    反应条件:1.1 Catalysts: Alumina,Iodine Solvents: Ethanol; 10 Min,Rt1.2 Reagents: Water; 12 Min,Rt
    标题:Iodine-Alumina As An Efficient And Useful Catalyst For The Regeneration Of Carbonyl Functionality From The Corresponding 1,3-Oxathiolanes And 1,3-Dithiolanes In Aqueous System
    作者:Rohman,Rumum Md.; Et Al
    参考文献:Tetrahedron Letters 日期:2010 卷标:51(21) 页码:2862-2864]

    150372-43-3 = 878-00-2
    反应条件:1.1 Reagents: Iodosylbenzene Solvents: Dichloromethane; 45 Min,Rt
    标题:Phio-Mediated Oxidative Dethioacetalization/dethioketalization Under Waterfree Conditions
    作者:Yu,Zhenyang; Et Al
    参考文献:Arkivoc (Gainesville 日期:2021 卷标:(7) 页码:48-65]

    7143-16-0 = 878-00-2
    反应条件:1.1 Reagents: Ceric Ammonium Nitrate Solvents: Dichloromethane
    标题:Deprotection Of Benzaldehyde Diacetates By Ceric Ammonium Nitrate Coated On Silica
    作者:Cotelle,Philippe; Et Al
    参考文献:Tetrahedron Letters 日期:1992 卷标:33(27) 页码:3855-8]

    465512-95-2 = 878-00-2
    反应条件:1.1 Catalysts: Alumina,Iodine Solvents: Ethanol; 10 Min,Rt1.2 Reagents: Water; 5 Min,Rt
    标题:Iodine-Alumina As An Efficient And Useful Catalyst For The Regeneration Of Carbonyl Functionality From The Corresponding 1,3-Oxathiolanes And 1,3-Dithiolanes In Aqueous System
    作者:Rohman,Rumum Md.; Et Al
    参考文献:Tetrahedron Letters 日期:2010 卷标:51(21) 页码:2862-2864]

    195054-29-6 = 878-00-2
    反应条件:1.1 Reagents: Water,Oxygen Catalysts: Bismuth Nitrate Solvents: Benzene1.2 Reagents: Water
    标题:A Catalytic Deprotection Of S,S- S,O- And O,O-Acetals Using Bi(No3)3.5 H2O Under Air
    作者:Komatsu,Naoki; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2001 卷标:343(5) 页码:473-480]

    195054-29-6 = 878-00-2
    反应条件:1.1 Reagents: Acetyl Chloride,Sodium Nitrite Solvents: Dichloromethane; 10 Min,0 - 5 °C1.2 Solvents: Dichloromethane; 5 Min,0 - 5 °C1.3 Reagents: Water; 5 °C -> Rt; 20 Min,Rt
    标题:A Highly Efficient Procedure For Regeneration Of Carbonyl Groups From Their Corresponding Oxathioacetals And Dithioacetals Using Sodium Nitrite And Acetyl Chloride In Dichloromethane
    作者:Khan,Abu T.; Et Al
    参考文献:Synlett 日期:2003 卷标:(3) 页码:377-381]

    6309-46-2 = 878-00-2
    反应条件:1.1 Reagents: Oxygen Catalysts: 2,2′-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Diammonium Salt,Laccase
    标题:A Mild,Simple And General Procedure For The Oxidation Of Benzyl Alcohols To Benzaldehydes
    作者:Rosenau,T.; Et Al
    参考文献:Synthetic Communications 日期:1996 卷标:26(2) 页码:315-20]

    6309-46-2 = 878-00-2
    反应条件:1.1 Reagents: Trichloroisocyanuric Acid,Water Solvents: Acetonitrile,Dichloromethane; 2 H,Rt
    标题:A Convenient Protocol For The Oxidation Of Benzyl And Secondary Alcohols To Carbonyl Compounds By Trichoroisocyanuric Acid
    作者:Dos Santos,Carlos Vinicius P.; Et Al
    参考文献:Letters In Organic Chemistry 日期:2021 卷标:18(11) 页码:854-861]

    6309-46-2 = 878-00-2
    反应条件:1.1 Catalysts: Benzene,Acridophosphino[2,1,10,9-Klmna]Acridophosphinium,6,12-Dihydro-6,6,12,12-Tetraph... Solvents: 2,2,2-Trifluoroethanol; 6 H,Rt
    标题:Selective Oxidation Of Benzylic Alcohols Via Synergistic Bisphosphonium And Cobalt Catalysis
    作者:Ding,Jia; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2023 卷标:59(27) 页码:4055-4058]

    757965-23-4 = 878-00-2
    反应条件:1.1 Catalysts: Iron Chloride (Fecl3),Poly(4-Vinylpyridine) Solvents: Dichloromethane; 5 H,Reflux; Reflux -> Rt
    标题:Polymer (Pvp) Supported Ferric Chloride As A Heterogeneous Catalyst For Selective Deprotection Of Aldoximes And Hydrazone
    作者:Chari,M. Adharvana; Et Al
    参考文献:Trends In Applied Sciences Research 日期:2007 卷标:2(1) 页码:80-84]

    33527-94-5 = 878-00-2
    反应条件:1.1 Reagents: Triethylamine,Triphenylphosphine,Iodine Catalysts: Palladium Diacetate Solvents: Toluene; 3 H,80 °C
    标题:A Magnetically Recyclable Palladium-Catalyzed Formylation Of Aryl Iodides With Formic Acid As Co Source: A Practical Access To Aromatic Aldehydes
    作者:You,Shengyong; Et Al
    参考文献:Synthesis 日期:2021 卷标:53(11) 页码:1962-1970]

    2345-34-8 = 878-00-2
    反应条件:1.1 Reagents: Triethylamine,Pinacolborane,Pyridinium,4-(1-Piperidinyl)-1-[(Trifluoromethyl)Sulfonyl]-,1,1,1-Trifluoromet... Solvents: Dichloromethane; 10 Min,Rt1.2 Reagents: Water; Rt
    标题:Triflylpyridinium Enables Rapid And Scalable Controlled Reduction Of Carboxylic Acids To Aldehydes Using Pinacolborane
    作者:Chen,Du; Et Al
    参考文献:Angewandte Chemie 日期:2023 卷标:62(2)]

    123-08-0 = 878-00-2
    反应条件:1.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 0 °C; 12 H,Rt
    标题:Synthesis,Characterization,And Antifungal Evaluation Of Thiolactomycin Derivatives
    作者:Lv,Pei; Et Al
    参考文献:Engineering (Beijing 日期:2020 卷标:6(5) 页码:560-568]

    38177-33-2 = 878-00-2
    反应条件:1.1 Reagents: Oxygen,Mercury Fluoride (Hgf2) Solvents: Acetonitrile; 24 H,25 °C
    标题:Photolytic Decarboxylation Of α-Aryl Carboxylic Acids Mediated By Hgf2 Under A Dioxygen Atmosphere
    作者:Farhadi,Saeid; Et Al
    参考文献:Tetrahedron Letters 日期:2006 卷标:47(12) 页码:1965-1968]

    402716-57-8 = 878-00-2
    反应条件:1.1 Reagents: Hydrogen Peroxide,Ammonium Bromide Catalysts: Perchloric Acid,Ammonium Molybdate ((Nh4)6Mo7O24) Tetrahydrate Solvents: Dichloromethane,Water
    标题:Oxidative Cleavage Of Diethyldithioacetals By Ammonium Bromide Promoted By (Nh4)6Mo7O24.4H2O-H2O2: A Useful Synthetic Protocol For Regeneration Of Carbonyl Compounds
    作者:Khan,Abu T.; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2001 卷标:(11) 页码:1039-1042]

    402716-57-8 = 878-00-2
    反应条件:1.1 Reagents: Vanadium Oxide (V2O5),Hydrogen Peroxide,Ammonium Bromide Solvents: Water
    标题:A Useful And Environmentally Benign Synthetic Protocol For Dethiolization By Employing Vanadium Pentoxide Catalyzed Oxidation Of Ammonium Bromide By Hydrogen Peroxide
    作者:Mondal,Ejabul; Et Al
    参考文献:Chemistry Letters 日期:2001 卷标:(11) 页码:1158-1159]

    123-08-0 = 878-00-2
    反应条件:1.1 Catalysts: Triacylglycerol Lipase Solvents: Tetrahydrofuran,Cyclohexane
    标题:Acetylation Of Phenols In Organic Solvent Catalyzed By A Lipase From Chromobacterium Viscosum
    作者:Nicolosi,Giovanni; Et Al
    参考文献:Tetrahedron 日期:1992 卷标:48(12) 页码:2477-82
乙酸对甲酚酯置于iron(Iii) Chloride体系中,用 乙腈 作为反应溶剂,以95 %的收率获得产物4-乙酰氧基苯甲醛
参考文献:密闭空气条件下光催化选择性氧化甲苯
标题:密闭空气条件下光催化选择性氧化甲苯
摘要:苯甲醛是化学中不可或缺的组成部分.然而,由于苯甲醛的氧化电位比甲苯低,因此甲苯选择性氧化为苯甲醛仍然是一个持续的挑战.我们在此报告了一种温和的方案,该方案将氢原子转移(hat)与封装的空气条件和合适的催化剂负载相结合,用于甲苯的选择性氧化,具有高选择性以及非常好的官能团耐受性和广泛的底物范围,用于合成各种高有价值的芳香醛.此外,该反应与生物活性分子的甲苯衍生物的相容性进一步证明了该方法的实用性.机理研究表明,氧量和hat催化体系之间的协同对反应的高选择性具有重要影响.这项研究不仅展示了 Hat 策略对甲苯选择性氧化为苯甲醛的有效性,而且还提供了一种控制 Hat 反应选择性的方法.
DOI:10.1039/d4Cc00915K

海关参考信息

专利信息


专利号:US-8193384-B2
优先权日:2005-07-29
标 题 :Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds
发明人:PARANG KEYKAVOUS; AHAMDIBENI YOUSEF
权利人:PARANG KEYKAVOUS; AHAMDIBENI YOUSEF; RHODE ISLAND EDUCATION
摘要:The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.

专利号:US-8410320-B2
优先权日:2010-12-07
标 题 :Method for synthesis of secondary alcohols
发明人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人:WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-8129520-B2
优先权日:2003-06-06
标题 :Methods and intermediates for the synthesis of dipyrrin-substituted porphyrinic macrocycles
发明人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S
权利人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S; UNIV NORTH CAROLINA STATE
摘要:The present invention provides dipyrrin substituted porphyrinic macrocycles, intermediates useful for making the same, and methods of making the same. Such compounds may be used for purposes including the making of molecular memory devices, solar cells and light harvesting arrays.

专利号:US-5877296-A
优先权日:1994-06-03
标题:Process for preparing conjugates of methyltrithio antitumor agents
发明人:HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN
权利人:AMERICAN CYANAMID CO
摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

专利号:US-6673543-B2
优先权日:2000-04-05
标 题:Solid phase synthesis of LXR ligands
发明人:MEDINA JULIO; IMAZAKI NAONORI
权利人:TULARIK INC; SUMITOMO PHARMA
摘要:The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic indicators of LXRα function and as pharmacologically active agents. The combinatorial libraries find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.
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✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Copper(I)‐catalyzed Cyclization Reactions Of Ethyl ( E )‐α‐ethynyl‐β‐aryl‐α,β‐unsaturated Esters With N ‐sulfonyl Azides: Synthesis Of 1‐aminonaphthalene, 3‐aminobenzofuran, And 3‐aminothiobenzofuran Derivatives
作者:Jeong‐yu Son,Gi Uk Han,Gi Hoon Ko,Chanyoung Maeng,Seohyun Shin,Phil Ho Lee |发布日期:2019.7
摘要:4‐(Alkyl Or Arylsulfonamido)‐2‐naphthoates From Ethyl (E)‐α‐ethynyl‐β‐aryl‐α,β‐unsaturated Esters (1) And N‐sulfonyl Azides (2) In The Presence Of 2,6‐lutidine In Thf At 60 °C For 3 H Was Developed In One Step, In Which A Copper(I)‐catalyzed 1,3‐dipolar Cycloaddition, Ketenimine Formation, And 6π‐electrocyclization Followed By [1,3]‐h Shift Tandem Reaction Took Place. This Method Enabled Efficient Synthesis

合成参考文献


摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2010) 47, 247.
摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 287.
摘要:Leung, M.-k.; Chou, C.-M.; Luh, T.-Y., Science of Synthesis Knowledge Updates, (2018) 2, 410.
摘要:Bartels, F.; Zimmer, R.; Christmann, M., Science of Synthesis Knowledge Updates, (2017) 3, 292.
摘要:Goldfuss, B., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 438.
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