CAS: 86906-05-0; (R)-2-Amino-1,1,3-Triphenylpropan-1-Ol

该化合物是一种手性氨基酒精衍生物,其特点是C-2位置的立体中心,使其成为非对称合成中有价值的中间体.其硬性三苯基基气柱骨干会增加消毒障碍,促进催化应用中的对应选择性转化.该化合物的氢氧基和安咪功能组提供多种衍生反应,包括用作有机化学和医药化学的离心或手性辅助剂.在温和条件下,高光学纯度和结构稳定性使其适合药物研究,特别是在生物活性分子合成方面.其晶体特性可以确保易于处理和定性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

D-(R)-phenylalanine D-phenylalanine methyl ester DL-2-Amino-1,1,3-triphenyl-1-propanol D-phenylalanine methyl ester hydr°Chloride (R)-4,4-diphenyl-5-benzyloxazolidin-2-thione (R)-N-acetyl-4,4-diphenyl-5-benzyloxazolidin-2-thione 1-((R)-4-Benzyl-5,5-diphenyl-2-thioxo-oxazolidin-3-yl)-2-{(2S,5S)-5-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-pentyl]-tetrahydro-furan-2-yl}-ethanone 2-hydroxybenzaldehyde ((2R)-1,1,3-triphenylpropanol) imine

合成工艺路线路线简述

  • 21685-51-8 = 86906-05-0
    反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; Rt1.2 8 H,Cooled1.3 Reagents: Ammonium Chloride Solvents: Water
    标题:Synthesis Of Chiral Amino Alcohol Palladium(Ii) Complexes
    作者:Bai,Haiyu; Et Al
    参考文献:Huagong Shikan 日期:2008 卷标:22(3) 页码:5-6]

    13033-84-6 = 86906-05-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Diethyl Ether,Water; 20 Min,Rt1.2 Solvents: Diethyl Ether; 0 °C; 0 °C -> Reflux; 9 H,Reflux
    标题:Highly Diastereoselective Synthesis Of Trans-2,5-Disubstituted Tetrahydrofurans
    作者:Jalce,Gael; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(9) 页码:3240-3241]

    13033-84-6 = 86906-05-0
    反应条件:1.1 Solvents: Diethyl Ether; 0 °C; 0 °C -> Rt; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Rt
    标题:Direct Asymmetric N-Specific Reaction Of Nitrosobenzene With Aldehydes Catalyzed By A Chiral Primary Amine-Based Organocatalyst
    作者:Qin,Long; Et Al
    参考文献:Chirality 日期:2011 卷标:23(7) 页码:527-533]

    673-06-3 = 86906-05-0
    反应条件:1.1 Reagents: Sulfuryl Chloride; 10 Min,-10 °C; 120 Min,Reflux2.1 Reagents: Sodium Hydroxide Solvents: Diethyl Ether,Water; 20 Min,Rt2.2 Solvents: Diethyl Ether; 0 °C; 0 °C -> Reflux; 9 H,Reflux
    标题:Highly Diastereoselective Synthesis Of Trans-2,5-Disubstituted Tetrahydrofurans
    作者:Jalce,Gael; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(9) 页码:3240-3241]

    57728-37-7 = 86906-05-0 + 79868-78-3
    反应条件:1.1 Catalysts: Palladium(2+),Bis[1,1′-(1S)-[1,1′-Binaphthalene]-2,2′-Diylbis[1,1-Diphenylphosp... Solvents: Chloroform-D; Rt
    标题:Chiral Discrimination By A Binuclear Pd Complex Sensor Using 31P{1H} Nmr
    作者:Chen,Zhongxiang; Et Al
    参考文献:Analytical Chemistry (Washington 日期:2019 卷标:91(22) 页码:14591-14596
📜D-苯丙氨酸置于乙醚,苯基溴化镁体系中,化学反应生成 (R)-(+)-2-氨基-1,1,3-三苯基-1-丙醇
参考文献:Mckenzie; Wills,Journal Of The Chemical Society,1925,Vol. 127,P. 284
标题:Mckenzie; Wills,Journal Of The Chemical Society,1925,Vol. 127,P. 284

海关参考信息

专利信息


专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:RU-2378252-C2
优先权日:2004-04-02
标题 :Novel method for synthesis of intermediate compounds, used in synthesis of vitamin d analogues

专利号:US-2007027333-A1
优先权日:2004-03-18
标题 :Stereoselective synthesis of vitamin d analogues

专利号:CA-2555260-C
优先权日:2004-03-18
标 题 :Stereoselective synthesis of vitamin d analogues

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主要参考文献

参考标题:Direct Asymmetric N-Specific Reaction Of Nitrosobenzene With Aldehydes Catalyzed By A Chiral Primary Amine-Based Organocatalyst
作者:Long Qin,Lei Li,Lei Yi,Chao-Shan Da,Yi-Feng Zhou |发布日期:2011.8
摘要:Interesting And Important To Perform A Nitrogen Or Oxygen Selective Reaction With Interesting Substrates. These Atom Specific Reactions Are Crucial To Specifically Synthesis Of Specific Compounds. An Enantioselective N‐specific Reaction Of Nitrosobenzene With Unmodified Aldehydes Was Successfully Achieved Catalyzed First By A Variety Of Primary Amine‐based Organocatalysts With Higher Yield And Enantioselectivity

合成参考文献

参考DOI号:10.1002/chir.20960
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