CAS: 857036-77-2; Cediranib Maleate

7-(苄氧基)-4-(4-氟-2-甲基-1H-吲哚-5-氧基)-6-甲氧基喹唑啉置于palladium 10% On Activated Carbon,氢气,Potassium Carbonate,甲烷体系中,用 N-甲基吡咯烷酮,异丙醇 作为反应溶剂,20.0~80.0 °C,101.33 Kpa 条件下,反应 8.08H,反应生成 西地尼布马来酸盐
参考文献:西地尼布盐及其晶型,以及其制备方法和药物组合物
标题:西地尼布盐及其晶型,以及其制备方法和药物组合物
摘要:本发明涉及西地尼布盐及其晶型,与现有技术相比,本发明的西地尼布盐及其晶型在水中具有更好的溶解度.本发明还涉及所述西地尼布盐及其晶型的制备方法,其药物组合物及其在制备用于治疗和/或预防病理性血管反应生成疾病的药物中的用途.

专利信息

专利号:WO-2025128098-A1
优先权日:2023-12-13
标 题 :Solid oral dosage forms, kits, and methods of using the same
发明人：LI YING; LANGER ROBERT; TRAVERSO CARLO
权利人:MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL INC
摘要:Provided herein are solid oral dosage forms, methods, and kits useful, e.g, for the extension of the residence time of active pharmaceutical agents in vivo by the synthesis of a polymer in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

专利号:US-12180228-B2
优先权日:2019-06-05
标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
发明人：MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

专利号:EP-3645600-A1
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof

专利号:CN-102603718-B
优先权日:2012-02-08
标 题:Synthesis method of cediranib