CAS: 84025-81-0; (R)-2-(Methoxymethyl)Pyrrolidine

该化合物是一种手性丙烯衍生物,在2号位置上具有一种甲基甲基甲基替代物,该化合物因其作为非对称合成,特别是制药和农用化学应用中多用途构件的作用而备受重视,其立体化学纯度(R-配置)有助于制造抗选择性催化剂或离子,增强反应选择性.甲基乙酰胺组提供了功能化潜力,在维持典型反应条件下的稳定性的同时,能够进一步衍生.其丙烯核心有助于符合性僵硬性,有助于生物活性分子的设计.该化合物一般在对湿度和空气的敏感度的惰性条件下处理.适合需要手动地雷中间体的研究和工业规模应用.

英文名称(R)-2-(Methoxymethyl)Pyrrolidine
中文名称(R)-2-(甲氧甲基)吡咯烷
IUPAC名称(R)-2-(methoxymethyl)pyrrolidine
其它别名(R)-(+)-2-(甲氧基甲基)吡咯烷; (R)-2-(Methoxymethyl)Pyrrolidine
CAS编号84025-81-0
MFCD编号:MFCD00066219
EINECS号:626-408-4
分子式:C6H13NO
分子量:115.17
产品CID: 1828614
产品分类有机原料→催化剂与配体→有机催化小分子→其它催化小分子

相似结构搜索
产品信息参考;;;;
InChIKey: CHPRFKYDQRKRRK-ZCFIWIBFSA-N
InChI=1S/C6H13NO/c1-8-5-6-3-2-4-7-6/h6-7H,2-5H2,1H3/t6-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

相似化合物

23356-96-9 498-63-5 63126-47-6

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS07;
注释: Flame & Exclamation mark
危险类别易燃液体类别3
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤腐蚀类别1C
警示词Warning(警告)
危险描述H226 |易燃液体和蒸气.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H314 |造成严重皮肤灼伤和眼损伤.
防范说明P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
危险等级3
UN编号1993.0
危险品标志Xi
包装等级Ⅲ
安全声明26-36
危险类别码10-36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

D-脯氨醇 D-Prolinol 68832-13-3

合成工艺路线路线简述

344-25-2 = 84025-81-0
反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; Rt; 1 H,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Water; 15 Min,Reflux1.3 Reagents: Methyl Formate; 1 H,0 °C; 2 H,0 °C1.4 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; -60 °C; Overnight,-60 °C -> Rt; 15 Min,Reflux1.5 Reagents: Hydrochloric Acid Solvents: Water1.6 Reagents: Potassium Hydroxide Solvents: Water; Rt; 5 H,Reflux
标题:Iterative Assembly Line Synthesis Of Polypropionates With Full Stereocontrol
作者:Bootwicha,Teerawut; Et Al
参考文献:Nature Chemistry 日期:2017 卷标:9(9) 页码:896-902

(2R)-2-(甲氧基甲基)吡咯烷盐酸盐置于sodium Hydroxide体系中,用水作为反应溶剂,化学反应生成 (R)-(-)-2-(甲氧基甲基)吡咯烷
参考文献:Application Of Chiral Transfer Reagents To Improve Stereoselectivity And Yields In The Synthesis Of The Antituberculosis Drug Bedaquiline
标题:Application Of Chiral Transfer Reagents To Improve Stereoselectivity And Yields In The Synthesis Of The Antituberculosis Drug Bedaquiline
摘要:
DOI:10.1021/acs.Oprd.3C00287

海关参考信息

2905121000-正丙醇
2905130000-正丁醇
2922110001-单乙醇胺
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:WO-2009030733-A1
优先权日:2007-09-04
标题 :Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIO; HANBAUER MARTIN HELMUT FRIEDRICK
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIA GERARDUS; HANBAUER MARTIN HELMUT FRIEDRI
摘要:The present invention relates to a method for the synthesis of enantiomerically and diastereomerically enriched 4-alkoxy-, 4-hydroxy- or 4-aryloxy- substituted tetrahydro-furo[3,4-b]furan-2(3H)-ones by aldol coupling of a suitable hydroxyl-protected hydroxy-acetaldehyde and 4-oxobutanoic acid or an ester thereof, and subsequent removal of the protecting group from the aldol compound and (optionally simultaneous) cyclizations and acetal formation under acidic conditions in the presence of an alcohol, followed by optional isolation of the desired compounds. The invention also relates to compounds according to formulae [Xl] and [XII].

专利号:WO-2009026961-A1
优先权日:2007-08-30
标题:Processes for the preparation of pancratistatin and pancratistatin analogues
发明人：ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
权利人:UNIV SANTIAGO COMPOSTELA; ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
摘要:Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a chiral amine is used. Reduction processes then give new and advanced intermediates that are useful for the preparation of pancratistatin or selected pancratistatin analogues. The reported process also provides a method for the efficient synthesis of nitroenals, starting materials of the synthesis. Analogues of pancratistatin are also provided.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-2007021436-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis