CAS: 82419-26-9; 2,3-Difluoro-6-Nitrophenol

化学文摘社编号为82419-26-9,是一个独特的识别资料,便于在化学数据库中识别该化合物.在处理和储存准则方面,应参考安全数据表,因为与硝化物和氟化合物有关的化合物可构成具体的健康和环境风险.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号771-69-7 2,3,4-三氟硝基苯 | CAS号82419-35-0 氟嗪羧酸 | CAS号82419-36-1 氧氟沙星 | CAS号82419-32-7 2-丙酮氧基-3,4-二氟硝基苯 | CAS号82419-33-8 7,8-二氟-2,3-二氢-3... | CAS号82419-52-1 9-氟-2,3二氢-3-甲基-... | CAS号66684-60-4 2,3-二氟-6-硝基苯甲醚 | CAS号115551-33-2 6-氨基-2,3-二氟苯酚 | CAS号329925-77-1 (2R)-N-(2-chlor... | CAS号124338-73-4 | CAS号124255-93-2 4-n-Propyl ofloxacin

合成工艺路线路线简述

  • 771-69-7 = 82419-26-9
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water
    标题:Synthesis Of Fluoroquinolone Antimicrobial Agent Ofloxacin
    作者:Wang,Erhua; Et Al
    参考文献:Zhongguo Yiyao Gongye Zazhi 日期:1991 卷标:22(9) 页码:385-7]

    393-79-3 = 82419-26-9 [标题:Reaction Conditions
    标题:Anti-Acid-Fast Bacteria Agents
    参考文献:Japan]

    393-79-3 = 82419-26-9 [标题:Reaction Conditions
    标题:2,3-Difluoro-6-Nitrophenol
    参考文献:Japan]

    169468-80-8 = 82419-26-9 + 123173-60-4
    反应条件:1.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C2.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C2.2 Reagents: Water; 0 - 5 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

    771-69-7 = 82419-26-9
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water
    标题:2,3-Difluoro-6-Nitrophenol
    参考文献:Germany]

    393-79-3 = 82419-26-9
    反应条件:1.1 Reagents: Potassium Fluoride Solvents: Dimethyl Sulfoxide,Toluene1.2 Reagents: Potassium Hydroxide Solvents: Water1.3 Reagents: Hydrochloric Acid
    标题:Method Of Producing 2,3-Difluoro-6-Nitrophenol
    参考文献:Czechoslovakia]

    169468-83-1 = 82419-26-9 [标题:Reaction Conditions
    标题:Pyrido[1,2,3-De][1,4]Benzoxazines
    参考文献:Japan]

    771-69-7 = 82419-26-9 + 123173-60-4
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C1.2 Reagents: Water; 0 - 5 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

    36556-47-5 = 82419-26-9 + 123173-60-4
    反应条件:1.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C2.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C3.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C3.2 Reagents: Water; 0 - 5 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

    958996-49-1 = 82419-26-9 + 123173-60-4
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C2.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C3.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C4.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C4.2 Reagents: Water; 0 - 5 °C4.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

    2646-83-5 = 82419-26-9 + 123173-60-4
    反应条件:1.1 Reagents: Chlorine Catalysts: Iron Chloride (Fecl3) Solvents: Chloroform; 10 H,25 - 35 °C; 2 H,30 - 35 °C2.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C3.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C4.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C5.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C5.2 Reagents: Water; 0 - 5 °C5.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

    = 82419-26-9 + 123173-60-4
    反应条件:1.1 10 H,495 - 505 °C2.1 Reagents: Chlorine Catalysts: Iron Chloride (Fecl3) Solvents: Chloroform; 10 H,25 - 35 °C; 2 H,30 - 35 °C3.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C4.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C5.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C6.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C6.2 Reagents: Water; 0 - 5 °C6.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
    标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
    作者:Volchkov,N. V.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163
2,3,4-三氟硝基苯置于氢氧化钾体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 2.0H,以29%的收率获得产物2,3-二氟-6-硝基苯酚
参考文献:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
标题:Synthesis And Antibacterial Activities Of Substituted 7-Oxo-2,3-Dihydro-7H-Pyrido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acids.
摘要:作为寻找新的合成抗菌剂以对抗全身感染的一部分,合成了多种7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸类似物.在合成的新化合物中,9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-2,3-二氢-7H-吡啶并[1,2,3-De][1,4]苯并噁嗪-6-羧酸(dl-8280)显示出对革兰氏阳性和阴性病原体,包括铜绿假单胞菌的强效抗菌活性,并且其代谢情况在单独的实验中显示为有利.
DOI:10.1248/cpb.32.4907

海关参考信息

专利信息


专利号:US-6448449-B2
优先权日:2000-04-21
标题:Process for preparation of (R)-1- (aryloxy)propan-2-ol
发明人：LARROW JAY FRANCIS
权利人:RHODIA CHIREX INC
摘要:A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol, which is a useful intermediate in the synthesis of the widely used antibiotic Levofloxacin is provided. A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-2-trimethylsiloxypropane is also described. The process includes the ring opening of (R)-propylene oxide with 2,3-difluoro-6-nitrophenyl trimethylsilyl ether in the presence of an optically active Co(salen) catalyst. The trimethylsilyl group of the reactant is transferred to the product aryloxy alcohol, which serves to protect the secondary alcohol in situ. Upon isolation, the trimethylsilyl group is removed and the resulting regioisomeric mixture purified to yield the desired (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol in high purity and yield.

专利号:WO-9407873-A1
优先权日:1992-10-07
标题 :Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof

其他信息查阅

阜新达得利化工股份有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证，请用户仔细辨别，谨慎交易。
数据来源于公开网络搜索，平台未作核实，请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.dudleychem.com
企业联系电话：17741815008;13695005683👤
📞阜新达得利化工股份有限公司 ⚠️参考联系方式
联系人：王总
电话：17741815008;13695005683
手机：18641848178
传真：0418-8229996
邮箱：office@dudleychem.com
通信地址: 辽宁省阜新县伊吗图氟产业开发区
邮编: 123000
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→

地址:辽宁省阜新县伊吗图氟产业开发区
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。
常州市晔泰精细化工研究所
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证，请用户仔细辨别，谨慎交易。
数据来源于公开网络搜索，平台未作核实，请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.yetaichem.com
企业联系电话：0519-83299352👤
📞常州市晔泰精细化工研究所 ⚠️参考联系方式
联系人：柳建华;朱立平
电话：0519-83299352
手机：013506110093
传真：0519-83975360
邮箱：liujh@hi2000.com
通信地址: 常州市南郊老312国道旁宣塘桥宣盛路9号
邮编: 213016
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→

地址:常州市南郊老312国道旁宣塘桥宣盛路9号
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。
第 1 / 1 页

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知