CAS: 77-93-0; Triethyl 2-Hydroxypropane-1,2,3-Tricarboxylate

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53798-97-3 77-94-1 121633-50-9

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CAS号64-17-5 乙醇 | CAS号77-92-9 柠檬酸 | CAS号67-56-1 甲醇 | CAS号77-89-4 乙酰柠檬酸三乙酯 | CAS号75-64-9 叔丁胺 | CAS号144-16-1 5-氧代-1,3-二氧戊环-4... | CAS号112535-39-4 (5-oxo-[1,3]dio... | CAS号77862-72-7 (5-Oxo-1,3-diox... | CAS号75-03-6 碘乙烷 | CAS号112031-19-3 triethyl 2-phen... | CAS号18960-42-4 2-hydroxypropan... | CAS号77-89-4 乙酰柠檬酸三乙酯 | CAS号77-92-9 柠檬酸 | CAS号4552-00-5 2-(1-(methoxyca... | CAS号101967-99-1 diethyl 6-oxopy... | CAS号1587-20-8 柠檬酸三甲酯 | CAS号1242516-58-0 1,2-diethyl-3-m...

5-氧代-1,3-二氧戊环-4,4-二乙酸置于甲醇,Sodium Hydroxide,Pig Liver Esterase,丙醛二乙基乙缩醛,Dowex 50Wx4,Phosphate Buffer Ph=7,三乙胺体系中,化学反应 26.0H,反应生成 柠檬酸三乙酯
参考文献:Regio-And Enantioselectivity Of The Enzyme-Catalyzed Hydrolysis Of Citric Acid Derivatives
标题:Regio-And Enantioselectivity Of The Enzyme-Catalyzed Hydrolysis Of Citric Acid Derivatives
摘要:The Hydrolysis Of Triethyl Citrate In The Presence Of Three Serine Proteases (Chymotrypsin,Subtilisin In Bpn',Is Subtilisin Carlsberg) Is Highly Regioselective And Gives The Symmetric Diester. Several Lipases And Proteases Have The Complementary Regioselectivity And Give The Chiral Diester. Pig Liver Esterase,Aspergillus Niger Lipase And Candida Antarctica Lipase Give The Chiral (R)-Diester With Good Regio-And Enantioselectivity. The Stereoselective Hydrolysis Of The Meso Citric Derivatives 7A,B In The Presence Of Candida Antarctica Lipase Gives The Corresponding (R)-Monoester. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0957-4166(98)00448-0

专利信息

专利号:US-7759520-B2
优先权日:1996-11-27
标 题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; YIN DONGHUA; HE YALI
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-6995284-B2
优先权日:2000-08-24
标题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-5359016-A
优先权日:1993-03-29
标 题 :Process for the synthesis of styrene-isoprene rubber
发明人：HSU WEN-LIANG; HALASA ADEL F; MATRANA BARRY A
权利人:GOODYEAR TIRE & RUBBER
摘要:The subject invention relates to a technique for synthesizing rubbery copolymers of styrene and isoprene. These rubbery copolymers exhibit an excellent combination of properties for utilization in tire tread rubber compounds. By utilizing these styrene-isoprene rubbers in tire treads, tires having improved wet skid resistance can be built without sacrificing rolling resistance or tread wear characteristics. This invention more specifically discloses a process for the synthesis of styrene-isoprene rubbers which comprises copolymerizing isoprene monomer and styrene monomer in an organic solvent in the presence of a catalyst system which is comprised of (a) a lithium initiator and (b) an alkyl tetrahydrofurfuryl ether modifier, wherein the molar ratio of the modifier to the lithitium initiator is within the range of 2:1 to 40:1. The subject invention further discloses a process for the synthesis of styrene-isoprene rubbers which comprises copolymerizing isoprene monomer and styrene monomer in an organic solvent in the presence of a catalyst system which is comprised of (a) a lithium initiator and (b) 2,2-ditetrahydrofurylpropane as a modifier, wherein the molar ratio of the modifier to the lithium initiator is within the range of 1:1 to 40:1.

专利号:US-2014255328-A1
优先权日:2013-03-11
标 题:Hydrothermal Synthesis of Zinc Phlogopite
发明人：MCGUIRE MEAGHAN CLARK; BULL IVOR; JOHNSON GEOFFREY MARK
权利人:BASF SE
摘要:This invention relates to a synthetically derived zinc phlogopite platelets, of superior platelet diameter, effect pigments comprising such synthetically derived platelets and methods of forming said substrates. More specifically the disclosure describes an improved hydrothermal synthesis of zinc phlogopite suitable as a platelets for interference pigments, barrier and flame retardant applications.

专利号:US-8647848-B2
优先权日:2008-06-13
标题:Enzymatic synthesis of sphingolipids
发明人：HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

专利号:US-9174920-B1
优先权日:2013-10-17
标题:Integrated process of distillation with side reactors for synthesis of organic acid esters
发明人：PANCHAL CHANDRAKANT B; PRINDLE JOHN C; KOLAH ASPI; MILLER DENNIS J; LIRA CARL T
权利人:E3TEC SERVICE LLC; UNIV MICHIGAN STATE
摘要:An integrated process and system for synthesis of organic-acid esters is provided. The method of synthesizing combines reaction and distillation where an organic acid and alcohol composition are passed through a distillation chamber having a plurality of zones. Side reactors are used for drawing off portions of the composition and then recycling them to the distillation column for further purification. Water is removed from a pre-reactor prior to insertion into the distillation column. An integrated heat integration system is contained within the distillation column for further purification and optimizing efficiency in the obtaining of the final product.