CAS: 76116-24-0; (R)-1-(3-Nitrophenyl)Ethanol

该化合物是一种手动芳香醇,在苯环的元体位置上有一个硝化物组,该化合物在有机合成中广泛用作中间体,特别是在制造抗生素纯药品和精细化学品方面,其立体特性(R)配置使其对非对称合成和催化应用很有价值.硝基乙醇组通过减少或替代增强回弹力,进一步发挥作用.高纯度和定义明确的立体化学确保手力分辨率和离心设计的一致性.在受控条件下,该化合物的使用通常在惰性大气中进行,以保持稳定性.存储建议通常包括防止光和湿度.

英文名称(R)-1-(3-Nitrophenyl)Ethanol
中文名称(R)-1-(3-硝基苯基)乙醇
IUPAC名称(R)-1-(3-nitrophenyl)ethan-1-ol
其它别名(R)-1-(3-Nitrophenyl)Ethanol; (1R)-1-(3-Nitrophenyl)Ethanol; (1R)-1-(3-Nitrophenyl)Ethan-1-Ol; (R)-(1-(3-Nitrophenyl))Ethanol; (R)-1-(3-Nitrophenyl)Ethan-1-Ol
CAS编号76116-24-0
MFCD编号:MFCD18339582
分子式:C8H9NO3
分子量:167.16
产品CID: 1753026
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: FRPQAVXDUWMFCK-ZCFIWIBFSA-N
InChI=1S/C8H9NO3/c1-6(10)7-3-2-4-8(5-7)9(11)12/h2-6,10H,1H3/t6-/m1/s1…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

1-(3-nitrophenyl)ethanol (-)-(S)-N,N-dimethyl-1-phenylethylamine acetic anhydride 3-Nitroacetophenone (R)-2-chloro-6-(1-(3-nitrophenyl)ethoxy)pyrazine (S)-1-(1-azidoethyl)-3-nitrobenzene (R)-1-(3-nitrophenyl)ethyl acetate (S)-1-(3 -nitrophenyl)ethan-1-amine

合成工艺路线路线简述

2-羟基-1-(3-硝基苯基)-1-乙酮置于4-二甲氨基吡啶,Sodium Tetrahydroborate,Geotrichum Sp,水体系中,用二氯甲烷,二甲基亚砜,N,N-二甲基甲酰胺作为反应溶剂,化学反应 56.0H,反应生成 (R)-1-(3-硝基苯基)乙醇
参考文献:Microbial Transformation Of 2-Hydroxy And 2-Acetoxy Ketones With Geotrichum Sp.
标题:Microbial Transformation Of 2-Hydroxy And 2-Acetoxy Ketones With Geotrichum Sp.
摘要:Biotransformation Of A Series Of O-,M-And P-Substituted Alpha-Hydroxy-And Alpha-Acetoxyphenylethanones 1A-H And 9A-G With Geotrichum Sp. Led To The Corresponding 1,2-Diols 2 And/or Monoacetates 10 In Moderate To Excellent Enantiomeric Excesses. Alpha-Hydroxy-And Alpha-Acetoxyphenylethanones And Their M-And P-Derivatives Gave Preponderantly The S-Configuration Products While In The Case Of The O-Derivatives R-Alcohol Was Provided As The Major Enantiomer. The Results Of Stereoselectivity Were Discussed. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0968-0896(00)00023-7