CAS: 749931-20-2; 4-Bromo-2-Fluoro-5-Methoxybenzaldehyde

上下游产品

2-氟-5-甲氧基苯甲醛 2-Fluoro-5-Methoxybenzaldehyde 105728-90-3
2-溴-4-氟苯甲醚 2-Bromo-4-Fluoro-1-Methoxybenzene 452-08-4

📜2-氟-5-甲氧基苯甲醛置于溴体系中,用 氯仿 作为反应溶剂,化学反应 120.0H,以60%的收率获得产物4-溴-2-氟-5-甲氧基苯甲醛
参考文献: Inhibitors Of Hepatitis C Virus Rna-Dependent Rna Polymerase,And Compositions And Treatments Using The Same[fr] Inhibiteurs De Polymerase D'Arn Dependant D'Arn Du Virus De L'Hepatite C Et Compositions Et Traitement Utilisant Ces Inhibiteurs
标题: Inhibitors Of Hepatitis C Virus Rna-Dependent Rna Polymerase,And Compositions And Treatments Using The Same[fr] Inhibiteurs De Polymerase D'Arn Dependant D'Arn Du Virus De L'Hepatite C Et Compositions Et Traitement Utilisant Ces Inhibiteurs
摘要:本发明提供了公式(4)的化合物,以及它们的药学上可接受的盐和溶剂化合物,这些化合物可用作肝炎病毒(hcv)聚合酶酶的抑制剂,并且也可用于治疗hcv感染的hcv感染的哺乳动物.本发明还提供了包含公式(4)的化合物,其药学上可接受的盐和溶剂的药物组合物.此外,本发明提供了制备公式(4)化合物的中间体化合物和方法.

专利信息

专利号:US-10793557-B2
优先权日:2018-04-03
标题 :Sting agonist compounds
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CHILDERS MATTHEW LLOYD; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW MARC; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIM JONGWON; LU MIN; OTTE RYAN D; TROTTER BENJAMIN WESLEY
权利人:MERCK SHARP & DOHME
摘要:Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-10730849-B2
优先权日:2016-10-04
标 题:Benzo[b]thiophene compounds as STING agonists
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CHANG WONSUK; CUMMING JARED N; HAIDLE ANDREW M; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIANG RUI; LIM JONGWON; LU MIN; OTTE RYAN D; SIU TONY; TROTTER BENJAMIN WESLEY; TYAGARAJAN SRIRAM
权利人:MERCK SHARP & DOHME
摘要:Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.