CAS: 74472-40-5; 2,2',3,4,6,6'-Hexachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,这些合成有机化学品以其环境持久性和潜在毒性而著称,该化合物由两个联苯环组成,六氯原子在特定位置被替换,有助于其稳定性和降解抗药性;在室温中通常是固体,具有低波动性;多种氯原子的存在会加剧其疏水性,导致生物体中的生物累积性,并可能对健康和环境造成有害影响;2,2',3,4,6,6'-六氯联苯已就其干扰内分泌特性和潜在致癌影响进行了研究;由于其环境持久性,它被归类为持久性有机污染物,并须遵守旨在减少其释放和暴露的国际条例;适当处理和处置对于减轻其对生态系统和人类健康的影响至关重要.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: JZFZCLFEPXCRCA-UHFFFAOYSA-N
- 1S/C12H4Cl6/c13-5-2-1-3-6(14)9(5)10-7(15)4-8(16)11(17)12(10)18/h1-4H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
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📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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