Benzyloxycarbonylglycylglutamic Acid置于palladium On Activated Charcoal 氢气体系中,用 甲醇,水 作为反应溶剂,化学反应生成 甘氨酰-L-谷氨酸 参考文献:Kalikhevich,V. N.; Churkina,S. I.; Martynov,V. F.,Journal Of General Chemistry Of The Ussr,1981,Vol. 51,P. 1690-1695 标题:Kalikhevich,V. N.; Churkina,S. I.; Martynov,V. F.,Journal Of General Chemistry Of The Ussr,1981,Vol. 51,P. 1690-1695
专利号:US-6593459-B1 优先权日:1998-06-16 标题:Synthetic glycosulfopeptides and methods of synthesis thereof 发明人:CUMMINGS RICHARD D; MCEVER RODGER P 权利人:UNIV OKLAHOMA 摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
专利号:US-6444460-B1 优先权日:1998-08-19 标 题:Microbial production of actinol 发明人:SHIMIZU SAKAYU; WADA MASARU 权利人:ROCHE VITAMINS INC 摘要:A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor, such as, nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids, such as, zeaxanthin.
专利号:US-2003124634-A1 优先权日:1996-04-30 标 题 :Novel proteins involved in the synthesis and assembly of O-antigen in pseudomonas aeruginosa 发明人:LAM JOSEPH S; BURROWS LORI L; CHARTER DEBORAH; KIEVIT TERESA DE 权利人:UNIV GUELPH 摘要:Novel nucleic acid molecules encoding proteins involved in the synthesis and assembly of O-antigen in P. aeruginosa ; and novel proteins encoded by the nucleic acid molecules are described. Methods are disclosed for detecting P.aeruginosa in a sample by determining the presence of the proteins or a nucleic acid molecule encoding the proteins in the sample.
专利号:SK-635190-A3 优先权日:1989-12-20 标题:Bcrf1 protein of epstein-barr virus being capable of inhibiting synthesis of gamma-interferon, expression vector for synthesis thereof, and pharmaceutical composition containing thereof
专利号:CA-2394414-A1 优先权日:1999-12-16 标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids
专利号:MX-PA02003819-A 优先权日:1999-11-29 标 题 :PROCEDURE FOR OBTAINING NUCLEIC ACIDS FROM A SAMPLE OF THE ENVIRONMENT, NUCLEIC ACIDS SO OBTAINED AND ITS APPLICATION IN THE SYNTHESIS OF COMPOUNDS.
[参考文献]: Koelle Gb, Et Al. Glycyl-L-Glutamine, A Precursor, And Glycyl-L-Glutamic Acid, A Neurotrophic Factor For Maintenance Of Acetylcholinesterase And Butyrylcholinesterase In The Preganglionically Denervated Superior Cervical Ganglion Of The Cat In Vivo. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7. [参考文献]: Yourick Jj, Et Al. Regeneration Of Acetylcholinesterase In Clonal Neuroblastoma-Glioma Hybrid Ng108-15 Cells After Soman Inhibition: Effect Of Glycyl-L-Glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37. [参考文献]: Balvinder S Vig, Et Al. Human Pept1 Pharmacophore Distinguishes Between Dipeptide Transport And Binding. J Med Chem. 2006 Jun 15;49(12):3636-44. [参考文献]: Christina Gatschelhofer, Et Al. Enantioseparation Of Glycyl-Dipeptides By Cec Using Particle-Loaded Monoliths Prepared By Ring-Opening Metathesis Polymerization (Romp). J Biochem Biophys Methods. 2006 Nov 30;69(1-2):67-77. [参考文献]: G B Koelle, Et Al. Glycyl-L-Glutamine, A Precursor, And Glycyl-L-Glutamic Acid, A Neurotrophic Factor For Maintenance Of Acetylcholinesterase And Butyrylcholinesterase In The Preganglionically Denervated Superior Cervical Ganglion Of The Cat In Vivo. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7.
合成参考文献
参考文献:10.1177/0148607196020004281 摘要:Himmelseher S, Pfenninger E, Herrmann P. Cerebrospinal and plasma amino acid concentrations after administration of i.v. glycyl-glutamine and glycyl-tyrosine containing amino acid solutions in humans. JPEN J Parenter Enteral Nutr. 1996 Jul;20(4):281–6. doi: 10.1177/0148607196020004281. 参考文献:10.1021/jm0511029 摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029. 参考文献:10.1186/s40793-015-0069-y 摘要:Meyer JL, Dillard BA, Rodgers JM, Ritchie KB, Paul VJ, Teplitski M. Draft genome sequence of Halomonas meridiana R1t3 isolated from the surface microbiota of the Caribbean Elkhorn coral Acropora palmata. Environmental Microbiome. 2015 Oct 07;10(1):75. doi: 10.1186/s40793-015-0069-y. 参考文献:10.1186/s40793-017-0220-z|10.1186/s40793-017-0283-x 摘要:Aserse AA, Woyke T, Kyrpides NC, Whitman WB, Lindström K. Draft genome sequences of Bradyrhizobium shewense sp. nov. ERR11T and Bradyrhizobium yuanmingense CCBAU 10071T. Environmental Microbiome. 2017 Dec 05;12(1):74. doi: 10.1186/s40793-017-0283-x.