CAS: 58479-68-8; (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-3,5-Dihydroxytetrahydro-2H-Pyran-2-yl)Oxy)-3,4-Dihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4,5-Dihydroxytetrahydro-2H-Pyran-2-Yl (4Ar,5R,6As,6Br,8Ar,10R,11S,12Ar,12Br,14Bs)-5,11-Dihydroxy-9,9-Bis(Hydroxymethyl)-2,2,6A,6B,12A-Pentamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylate
该化合物是一种主要源于传统医学,特别是东亚传统医学常用植物Platycodon grandiflorus的根部的三元素沙邦素,因其各种生物活动而闻名,包括防炎,免疫分子和抗癌特性; 普拉蒂科丁D的化学结构具有水坝型骨骼,有助于其生物活动; 典型的特点是其在水和有机溶剂中的溶性,尽管其溶性因溶剂的不同而不同; 普蒂科丁D是研究其药理学影响,包括其加强呼吸健康的潜力及其在调控免疫反应中的作用的多项研究的主题; 此外,它对某些癌症细胞线产生了细胞毒性效应,使其成为癌症研究的复合物; 与许多自然产品一样,提取和净化过程可以影响其功效和生物利用率,强调适当分析技术在研究其特性和应用方面的重要性.
- 英文名称(2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-3,5-Dihydroxytetrahydro-2H-Pyran-2-yl)Oxy)-3,4-Dihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4,5-Dihydroxytetrahydro-2H-Pyran-2-Yl (4Ar,5R,6As,6Br,8Ar,10R,11S,12Ar,12Br,14Bs)-5,11-Dihydroxy-9,9-Bis(Hydroxymethyl)-2,2,6A,6B,12A-Pentamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylate
- 中文名称桔梗皂苷D
- IUPAC名称(2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-yl (4aR,5R,6aS,6bR,8aR,10R,11S,12aR,12bR,14bS)-5,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
- 其它别名桔梗皂甙D
- CAS编号58479-68-8
- MFCD编号:MFCD09952590
- EINECS号:683-210-0
- FDA UNII编号:CWJ06TA2GI
- 分子式:C57H92O28分子量:1225.33
- 产品CID: 1559528
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号66779-34-8 桔梗皂苷A | CAS号66779-35-9 3''-O-acetylpla...合成工艺路线路线简述
📜桔梗皂苷a置于氢氧化钾体系中,用 甲醇 作为反应溶剂,化学反应 0.5H,反应生成 桔梗皂苷d
参考文献:桔梗根中的皂苷.第2部分.新三萜糖苷的分离与结构
标题:桔梗根中的皂苷.第2部分.新三萜糖苷的分离与结构
摘要:从桔梗的根中分离出十七种新的皂苷(2)-(18).通过比较它们的13 C NMR信号与已知的促红素原素(19)-(26)以及铂蛋白d中的c-28的糖链来确定其结构(1).发现这些皂苷中的八个具有o-乙酰基,其在糖链中鼠李糖部分的2-O-和3-O-位置之间容易且可逆地迁移.
DOI:10.1039/p19840000661
海关参考信息
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2901220000-丙烯
2905122000-异丙醇
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专利信息
专利号:CN-120060184-A
优先权日:2025-02-27
标 题 :Application of PgUGT29 in the synthesis of platycodon saponin D3
专利号:US-2021290651-A1
优先权日:2020-03-20
标 题:Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:US-2021308117-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:US-2021315880-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:WO-2021189018-A9
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1055/s-1999-14021
摘要:Tsuyoshi Saeki, Kazuo Koike, Tamotsu Nikaido. A Comparative Study on Commercial, Botanical Gardens and Wild Samples of the Roots of Platycodon grandiflorum by HPLC Analysis. Planta med. 1999 Jun;65(5):428–31. doi: 10.1055/s-1999-14021.
参考文献:10.1002/ijc.23442
摘要:Kim MO, Moon DO, Choi YH, Lee JD, Kim ND, Kim GY. Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. Int J Cancer. 2008 Jun 15;122(12):2674–81. doi: 10.1002/ijc.23442.
参考文献:10.1016/j.phymed.2014.04.011
摘要:Choi JH, Jin SW, Han EH, Park BH, Kim HG, Khanal T, Hwang YP, Do MT, Lee HS, Chung YC, Kim HS, Jeong TC, Jeong HG. Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Phytomedicine. 2014 Jul;21(8-9):1053–61. doi: 10.1016/j.phymed.2014.04.011.
参考文献:10.1142/s0192415x04001916
摘要:Choi SS, Han EJ, Lee TH, Han KJ, Lee HK, Suh HW. Antinociceptive profiles of platycodin D in the mouse. Am J Chin Med. 2004;32(2):257–68. doi: 10.1142/s0192415x04001916.
参考文献:10.1002/ptr.2394
摘要:Choi YH, Kim YS, Yeo SJ, Roh SH, Jeong YC, Kang JS, Ryu SY. Ameliorating effect of balloon flower saponin on the ethanol-induced memory impairment in mice. Phytother Res. 2008 Jul;22(7):973–6. doi: 10.1002/ptr.2394.
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