CAS: 58196-33-1; 7-Hydroxy-1,2,3,4-Tetrahydroquinoline

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📜7-甲氧基-2,3-二氢喹啉-4-酮置于palladium On Activated Charcoal 4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,氢气,三溴化硼,溶剂黄146体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应生成 7-羟基-1,2,3,4-四氢喹啉
参考文献:Nonsteroidal Androgen Receptor Agonists Based On 4-(Trifluoromethyl)-2H-Pyrano[3,2-G]Quinolin-2-One
标题:Nonsteroidal Androgen Receptor Agonists Based On 4-(Trifluoromethyl)-2H-Pyrano[3,2-G]Quinolin-2-One
摘要:A Series Of 2H-Pyrano[3,2-G]Quinolin-2-Ones Was Prepared And Tested For The Ability To Modulate The Transcriptional Activity Of The Human Androgen Receptor (Har). The Parent Compound,4-(Trifluoromethyl)-2H-Pyrano[3,2-G]Quinolin-2-One,Displayed Moderate Interaction With Har,But Substituted Analogues Were Potent Har Modulators In Vitro As Mesaured By An Har Cotransfection Assay In Cv-I Cells And Bound To Har With High Affinity In A Whole Cell Assay. Several Analogues Were Able To Activate Har-Mediated Gene Transcription More Potently And Efficaciously Than Dihydrotestosterone. (C) 1999 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(99)00118-3

专利信息

专利号:US-5283336-A
优先权日:1992-09-08
标 题 :Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline
发明人：FIELD GEORGE; HAMMOND PETER R
权利人:US ARMY
摘要:Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

专利号:US-4622400-A
优先权日:1983-12-29
标 题:Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes
发明人：HAMMOND PETER R
权利人:US ENERGY
摘要:Methods are provided for making certain m-aminophenols using a sulfonation/alkali fusion procedure. The aminophenols are key intermediates in the synthesis of dyes, particularly efficient, stable dyes for laser application. Preparations of some rhodamine and phenoxazone dyes from the m-aminophenols are described.