CAS: 5349-17-7; 2-Bromo-1-(Pyridin-4-yl)Ethanone Hydrobromide

相似化合物

1122-54-9 478553-86-5 6221-13-2

上下游产品

CAS号1122-54-9 4-乙酰基吡啶 | CAS号350-03-8 3-乙酰吡啶 | CAS号30235-28-0 4-(4-吡啶基)-2-氨基噻唑 | CAS号845714-00-3 1,5,6,7-四氢-2-(4... | CAS号315702-99-9 N-(3-甲基苯基)-4-(4... | CAS号1342278-01-6 1-(3-羟基苄基)-3-[4... | CAS号610270-72-9 2-(2-OXO-2-(PYR... | CAS号61889-63-2 N-(4-methoxyphe...

📜4-乙酰吡啶置于溴体系中,用 氯仿 作为反应溶剂,化学反应生成 4-(溴乙酰基)吡啶氢溴酸盐
参考文献:新型吡啶基-羰基噻唑类化合物的合成,抗氧化和抗菌性能
标题:新型吡啶基-羰基噻唑类化合物的合成,抗氧化和抗菌性能
摘要:海洋化合物树状蛇毒碱首先从被膜类(dendrodo Grossularia)获得.它有一个五元环,也就是一个杂环噻二唑,在自然资源中很少见到.随着其生物学活性,最近研发了新的类似物.用于该研究的类似物的合成是通过不常见的噻唑封闭,包括亚甲基-羰基缩合实现的.通过NMR(1,13 C)和hrms光谱阐明结构.作为生物碱衍生物,通过dpph和frap分析评估了抗氧化性能,并通过微量稀释法评估了其抗菌效果.在这些系列中,3Bc-3Cf的抗氧化活性比具有3或4-吡啶基取代基的抗氧化活性高.对于含2-吡啶基的基团,2-吡啶基的活性较小,这可能是分子内相互作用的结果.在250μg/ Ml下未观测到针对革兰氏阴性细菌的活性.3Ae和3Ce显示出对金黄色葡萄球菌的活性为64μg/ Ml,而3Ae显示出对表皮葡萄球菌革兰氏阳性菌的活性为16μg/ Ml.氯霉素以8-16μg/ Ml的浓度显示出对所有微生
DOI:10.3906/kim-2008-8

专利信息

专利号:WO-2015088565-A1
优先权日:2013-12-13
标题:P2x4 receptor modulating compounds and methods of use thereof
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.