CAS: 487-27-4; (2R,3As,5R,6R,6Ar)-Rel-4-Methylhexahydro-2H-2,5-Methanofuro[3,2-B]Pyrrol-6-Ol
该化合物是一种化学化合物,属于藻类类别,具体来自该植物,其特征是其结构与其他对硫烷藻类相似,其特点是它与其他对硫烷藻类具有结构相似性,后者通常具有含有氮原子的双环结构.Scopoline 物证药理特性,包括可能影响...
- 英文名称(2R,3As,5R,6R,6Ar)-Rel-4-Methylhexahydro-2H-2,5-Methanofuro[3,2-B]Pyrrol-6-Ol
- 中文名称莨菪灵
- IUPAC名称(2R,3aS,5R,6R,6aR)-4-methylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-6-ol
- CAS编号487-27-4
- MFCD编号:MFCD07783424
- EINECS号:207-655-3
- FDA UNII编号:UGW80D8GKZ
- 分子式:C8H13NO2分子量:155.2
- 产品CID: 1479032
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
- 熔点107-109 °C
- 沸点248 °Cat 760 mmHg
- 闪点111.6 °C
- 密度1.284 g/cm3
- pKa:13.96±0.20(预测)
- PSA:32.7
- LogP:-0.471
- 折射率1.573
- 蒸汽压0.00403mmHg at 25°C
- 溶解性DMF:2.0(Max Conc. mg/mL);12.89(Max Conc. Mm) DMSO:1.0(Max Conc. mg/mL);6.44(Max Conc. Mm) Ethanol:3.0(Max Conc. mg/mL);19.33(Max Conc. Mm) Pbs (Ph: 7.2):5.0(Max Conc. mg/mL);32.22(Max Conc. Mm)
- 外观形态白色至类白色固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种在D. DIENTA混合体中发现的TOPANE ALKALOID.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号74-89-5 氨基甲烷 | CAS号92-61-5 东莨菪内酯； 莨菪亭合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2013046138-A1
优先权日:2011-09-27
标 题:Process for the preparation of scopine esters
发明人：CIPOLLONE AMALIA; FATTORI DANIELA; FINCHAM CHRISTOFER INGO
权利人:LUSOCHIMICA SPA
摘要:The present invention relates to a process for the preparation of scopine esters, as intermediates in the synthesis of tiotropium bromide. In particular, it relates to a transesterification process between scopine alcohol and an ester of a carboxyl acid in high yields and under conditions suitable for industrial use.
专利号:WO-2013135219-A1
优先权日:2012-03-16
标 题 :A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide, and its new form
专利号:EP-2825535-A1
优先权日:2012-03-16
标题:A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide, and its new form
专利号:EP-2831068-A1
优先权日:2012-03-30
标题 :A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide
专利号:HU-E029555-T2
优先权日:2012-03-16
标题:A method for the preparation of a scopine ester of di- (2-thienyl) glycolic acid, an intermediate of the synthesis of tiotropium bromide, and a novel form thereof
专利号:EP-2831068-B1
优先权日:2012-03-30
标 题 :A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide
发明人：CERNA IGOR; HAJICEK JOSEF
权利人:ZENTIVA KS
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Torrents-Masoliver B, Terriente-Palacios C, Bover-Cid S, Jofré A, Castellari M, Ribas-Agustí A. Effect of pH and temperature on tropane alkaloids within a processing strategy to provide safe infant cereal-based food. Food Res Int. 2024 Jul;188:114439. doi: 10.1016/j.foodres.2024.114439. Epub 2024 May 6.
3:100036. doi: 10.1016/j.fochms.2021.100036.
4: Marín-Sáez J, Romero-González R, Garrido Frenich A. Multi-analysis determination of tropane alkaloids in cereals and solanaceaes seeds by liquid chromatography coupled to single stage Exactive-Orbitrap. J Chromatogr A. 2017 Oct 6;1518:46-58. doi: 10.1016/j.chroma.2017.08.052. Epub 2017 Aug 25. 17(19):3030-3034. doi: 10.1002/cphc.201600368. Epub 2016 Jul 28. 87(17):8748-57. doi: 10.1021/acs.analchem.5b01611. Epub 2015 Aug 18. 14(9):1830-5. doi: 10.1002/cphc.201300199. Epub 2013 May 2. 325(1):17-22. German. doi: 10.1002/ardp.19923250106. 73(4):561-3. doi: 10.1002/jps.2600730432. 64(2):288-91. doi: 10.1002/jps.2600640220. 22(12):488-490.
合成参考文献
参考文献:10.1038/ncb3255
摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
📝 需求与反馈
尽可能描述清楚需求与问题信息
