CAS: 475-75-2; 8H-[1,3]Dioxolo[4',5':4,5]Benzo[1,2,3-De]Benzo[g]Quinolin-8-One

该化合物是一种天然的顺质藻类,自然地出现在几个植物物种中,特别是在安诺纳塞亚家族中,它展示了僵硬的四环结构,有助于其显著的生物活动. 研究凸显了它作为抗微生物,抗沙素和抗炎剂的潜力,对各种癌症细胞线和病原性微生物具有明显效力. 它的行动机制包括将DNA相互放大和抑制多孔异构体酶,干扰细胞复制. 利奥登因的稳定性和选择性细胞毒性使它成为有前途的药物开发的手脚. 分析研究证实它的纯性和结构完整性,确保研究应用中的再生性. 进一步的调查探索其药理和结构活动关系,以优化治疗潜力.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号103769-50-2 secoroemerine | CAS号2030-53-7 阿朴雷因 | CAS号87489-85-8 (2-bromophenyl)... | CAS号7224-93-3 1,4-bis(2-triph... | CAS号7241-00-1 (-)-anonaine | CAS号87489-86-9 1-(2'-bromo-α-h... | CAS号103769-52-4 N-carbethoxysec...

合成工艺路线路线简述

    📜1-(2'-Bromobenzyl)-3,4-Dihydro-6,7-Methylenedioxyisoquinoline置于盐酸,Sodium Tetrahydroborate,Di-Tert-Butyl(Methyl)Phosphonium Tetrafluoroborate Salt,氧气,Copper Diacetate,Palladium Diacetate,Potassium Carbonate体系中,用 1,4-二氧六环,甲醇,N,N-二甲基乙酰胺,N,N-二甲基甲酰胺 作为反应溶剂,130.0 °C,101.33 Kpa 条件下,反应 55.5H,反应生成 鹅掌楸碱
    参考文献:Pd(oac)2催化的c N,Cc和c(sp 3)-H键串联氧化的发展:1-芳基异喹啉,氧磷卟啉和8-氧原小ber碱生物碱的简捷合成
    标题:Pd(oac)2催化的c N,Cc和c(sp 3)-H键串联氧化的发展:1-芳基异喹啉,氧磷卟啉和8-氧原小ber碱生物碱的简捷合成
    摘要:开发了c N,Cc和c(sp 3)-h键的催化串联氧化反应.该串联氧化被应用于罂粟碱和普洛西汀a的两步全合成.另外,通过应用该催化串联氧化,从高哌啶醇和2-溴苯基乙腈的六步合成实现了鹅绒den碱的全合成.此外,木糖精以76%的产率直接转化为8-氧伪伪巴马汀证明了该催化反应的多功能性.
    DOI:10.1016/j.Tetlet.2020.152599

    海关参考信息

    专利信息


    专利号:US-8309599-B2
    优先权日:2006-09-08
    标题 :Synthesis of FR901464 and analogs with antitumor activity
    发明人：KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN
    权利人:KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN; UNIV PITTSBURGH
    摘要:The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

    专利号:US-2008096879-A1
    优先权日:2006-09-08
    标题:Synthesis of fr901464 and analogs with antitumor activity

    专利号:US-7825267-B2
    优先权日:2006-09-08
    标 题 :Synthesis of FR901464 and analogs with antitumor activity

    专利号:US-2011086909-A1
    优先权日:2006-09-08
    标题:Synthesis of fr901464 and analogs with antitumor activity

    专利号:WO-2011131816-A1
    优先权日:2010-04-19
    标 题 :Synthesis of oxoisoaporphine derivatives and the uses thereof as antimalarial agents

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Wu G, Chen G, Zhou J, Zhu H, Chu J, Zhang F. Liriodenine enhances radiosensitivity in esophageal cancer ECA-109 cells by inducing apoptosis and G2/M arrest. Oncol Lett. 2018 Oct;16(4):5020-5026. doi: 10.3892/ol.2018.9253. Epub 2018 Aug 2.
    2: Vinche ADL, de-la-Cruz-Chacón I, González-Esquinca AR, da Silva JF, Ferreira G, Dos Santos DC, Garces HG, de Oliveira DVM, Marçon C, Cavalcante RS, Mendes RP. Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genus Paracoccidioides. J Venom Anim Toxins Incl Trop Dis. 2020 Oct 28;26:e20200023. doi: 10.1590/1678-9199-JVATITD-2020-0023.
    3: De la Cruz-Chacón I, González-Esquinca AR, Guevara Fefer P, Jímenez Garcia LF. Liriodenine, early antimicrobial defence in Annona diversifolia. Z Naturforsch C J Biosci. 2011 Jul-Aug;66(7-8):377-84. doi: 10.1515/znc-2011-7-809. 14(2):1979-1984. doi: 10.3892/ol.2017.6418. Epub 2017 Jun 19.

    合成参考文献


    摘要:Pharmaceutical Research., 4(495), 1987 []
    参考文献:10.1007/s00436-020-06787-0
    摘要:Ghodsian S, Taghipour N, Deravi N, Behniafar H, Lasjerdi Z. Recent researches in effective antileishmanial herbal compounds: narrative review. Parasitol Res. 2020 Dec;119(12):3929–46. doi: 10.1007/s00436-020-06787-0.
    参考文献:10.1007/bf02253669|10.1159/000025413
    摘要:Su MJ, Chen WP, Lo TY, Wu TS. Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart. J Biomed Sci. 1999 Nov;6(6):376–86. doi: 10.1007/bf02253669.
    参考文献:10.1007/bf02253670|10.1159/000025414
    摘要:Huang C, Su M. Positive Inotropic Action of NMDA Receptor Antagonist (+)-MK801 in Rat Heart. Journal of Biomedical Science. 1999 Oct 22;6(6):387–98. doi: 10.1159/000025414.
    参考文献:10.1002/ptr.1318
    摘要:Khamis S, Bibby MC, Brown JE, Cooper PA, Scowen I, Wright CW. Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a malaysian plant used traditionally for the treatment of breast cancer. Phytother Res. 2004 Jul;18(7):507–10. doi: 10.1002/ptr.1318.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知