CAS: 36016-38-3; N-Tert-Butoxycarbonylhydroxylamine

相似化合物

29601-98-7 4229-44-1 5470-11-1

上下游产品

N-(tert-butyloxycarbonyl) azide tert-butyl dicarbonatedi-tert-butyl dicarbonate hydroxylamine hydr°Chloride t-butoxycarbonylhydrazineN,N-di(tert-butoxycarbonyl)hydroxylamine (benzyloxy)carbamic acid 1,1-dimethylethyl ester (acetyloxy)carbamic acid 1,1-dimethyl ethyl ester tert-butyl N-tosyloxycarbamate

叔-丁基氯甲酸酯置于盐酸羟胺,Sodium Hydroxide体系中,化学反应生成 N-羟基氨基甲酸叔丁酯
参考文献:α-亚硝基苯乙烯作为 (3+1) 环化反应的三原子单元:容易获得 2,3-二氢二氮杂氮氧化物及其多样化的合成转化
标题:α-亚硝基苯乙烯作为 (3+1) 环化反应的三原子单元:容易获得 2,3-二氢二氮杂氮氧化物及其多样化的合成转化
摘要:开发了由 α-溴肟和n-甲苯磺酰氧基氨基甲酸酯原位反应生成的 α-亚硝基苯乙烯的前所未有的 (3+1) 环化,这使得能够合成一系列结构独特且迄今为止尚未开发的 2,3-二氢二氮杂氮氧化物中到高产.该产品具有高度应变的四元环结构,包含两个氮原子.产品的合成适用性也通过许多重要的转化为不同的含氮化合物来证明.
DOI:10.1021/acs.Orglett.2C00024

专利信息

专利号:WO-9804535-A1
优先权日:1996-07-26
标 题 :A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
权利人:DU PONT MERCK PHARMA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of formula (VI-a) is particularly effective in the treatment of HIV.

专利号:US-6348616-B1
优先权日:1996-07-26
标题 :Practical synthesis of benzoxazinones useful as HIV reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of the formula:is particularly effective in the treatment of HIV.

专利号:US-7842813-B2
优先权日:2008-05-09
标 题 :Processes for the preparation of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine
发明人：TANG DATONG; HAN YINGLIN; HUANG YANHE; PHAN LY TAM; OR YAT SUN; WANG ZHE
权利人:ENANTA PHARM INC
摘要:The present invention relates generally to novel methods for the synthesis of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

专利号:US-7820858-B2
优先权日:2006-03-25
标 题 :Concise β2-amino acid synthesis via organocatalytic aminomethylation
发明人：CHI YONGGUI; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; HORNE WILLIAM S; GUO LI; ENGLISH EMILY P
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of β 2 -amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β 2 -amino acids.

专利号:US-4965343-A
优先权日:1988-01-28
标题 :Method of peptide synthesis
发明人：FELIX ARTHUR M; FOURNIER ALAIN; DANHO WALEED
权利人:HOFFMANN LA ROCHE
摘要:A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.

专利号:US-8987504-B2
优先权日:2010-06-18
标题 :Aminohydroxylation of alkenes
发明人：MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL
权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD
摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.