CAS: 35342-88-2; N,O-Bis((Trimethylsilyl)Oxy)Acetamide

📜Trimethylsilyl N-Trimethylsilyl-N-(Trimethylsiloxy)Carbamate置于氨体系中,用 正己烷 作为反应溶剂,化学反应 1.0H,以75%的收率获得产物n,O-双(三甲基硅基)氨基甲酸
参考文献:Sheludyakov,V. D.; Gusev,A. I.; Dmitrieva,A. B.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 10,P. 2051-2054
标题:Sheludyakov,V. D.; Gusev,A. I.; Dmitrieva,A. B.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 10,P. 2051-2054

专利信息

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

专利号:US-11952324-B2
优先权日:2017-08-04
标 题 :Amidoamine synthesis, methods to track the reaction process
发明人：KHRAMOV DIMITRI M; CHEN YIYAN; OKHRIMENKO ALBERT
权利人:MI LLC; SCHLUMBERGER TECHNOLOGY CORP
摘要:Methods may include quantifying the concentration of residual free amine and/or free carboxylic acid in a product mixture prepared from a reaction of a multireactive species and a fatty reagent; verifying that the concentration for the free amine and/or free acid in the product mixture is within an acceptable threshold for a given application; and combining the product mixture with one or more wellbore fluid components to generate the wellbore fluid. In another aspect, methods may include including reacting the multireactive species and a fatty reactant to generate a product mixture; quantifying the concentration of residual free amine and/or free carboxylic acid in the product mixture; verifying that the concentration for the free amine and/or free acid in the product mixture is within an acceptable threshold for a given application; and collecting the product mixture.

专利号:US-6080855-A
优先权日:1992-01-22
标题:2-isocephem and oxacephem derivatives and use as antibacterial agents
发明人：BURTON GEORGE; GASSON BRIAN CHARLES; FELL STEPHEN CHRISTOPHER MARTI
权利人:PFIZER
摘要:Compounds of formula (I) or salts thereof: ##STR1## wherein R 1 is hydrogen, methoxy or formamido; R 2 is an acyl group; CO 2 R 3 is a carboxy group or a carboxylate anion, or R 3 is a carboxy protecting group, pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R 4 represents hydrogen or up to four substituents; X is O, S, SO or SO 2 ; Y is O, S, SO or SO 2 ; n is 0 or 1; and m is 1 or 2. The compounds have antibacterial activity. Methods of synthesis of, and pharmaceutical formulations containing, compounds (I) are also described.

专利号:US-2018222936-A1
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids

专利号:US-4496754-A
优先权日:1982-12-28
标题 :Silyl carbamates and synthesis thereof
发明人：KANNER BERNARD; HOPPER STEVEN P; SEPELAK DENNIS J
权利人:UNION CARBIDE CORP
摘要:Silyl carbamates are produced by the reaction under suitable reaction conditions of silanes bearing at least one silicon-hydrogen bond of the formula: R 4-x SiH x with an ammonium carbamate of the formula: R'R'NH 2 .sup.⊕ R'R'NCO 2 .sup.⊖. This novel route is much simpler and more direct than those previously known and provides a new classes of silyl carbamates.

专利号:CA-2842358-A1
优先权日:2011-07-19
标题 :Methods for the synthesis of functionalized nucleic acids