专利号:WO-03059914-A1 优先权日:2002-01-15 标 题 :An improved synthesis of ceftiofur intermediate 发明人:DESHPANDE PRAMOD NARAYAN; KHADANGALE BHAUSAHEB PANDHARIN; KUMAR SURULICHAMY SENTHIL; DAS GAUTAM KUMAR 权利人:ORCHID CHEMICALS & PHARM LTD; DESHPANDE PRAMOD NARAYAN; KHADANGALE BHAUSAHEB PANDHARIN; KUMAR SURULICHAMY SENTHIL; DAS GAUTAM KUMAR 摘要:The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) represented by formula (II) with furyl-2-carbonylthiol represented by formula (III) using borontrifluoride as condensing agent in an organic solvent at a temperature range of 20 DEG -50 DEG C.
专利号:US-6803461-B2 优先权日:2002-01-04 标 题 :Synthesis of ceftiofur intermediate 发明人:DESHPANDE PRAMOD NARAYAN; KHADANGALE BHAUSAHEB PANDHARIN; KUMAR SURULICHAMY SENTHIL; DAS GAUTAM KUMAR 权利人:ORCHID CHEMICALS & PHARM LTD 摘要:The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
专利号:FR-2881741-A1 优先权日:2005-02-07 标题:PROCESS FOR THE SYNTHESIS OF CYSTEINE DERIVATIVES, IN PARTICULAR THIOCARBAESTER, USEFUL AS INTERMEDIATE PRODUCTS IN THE SYNTHESIS OF DRUGS
专利号:US-2003130502-A1 优先权日:2002-01-04 标 题:Synthesis of ceftiofur intermediate
专利号:US-2003135041-A1 优先权日:2002-01-04 标 题 :Synthesis of ceftiofur intermediate
专利号:CN-114957258-A 优先权日:2021-02-25 标题 :Synthesis of a broad-spectrum serine β-lactamase inhibitor based on carbapenem structure and its application in the inhibition of drug-resistant bacteria