专利号:US-2024279231-A1 优先权日:2021-05-20 标题:Map4k4 inhibitors and methods of synthesis and use thereof 发明人:AWASTHI VIBHUDUTTA; EEDA VENKATESWARARAO 权利人:UNIV OKLAHOMA 摘要:The compound DMX-5804, IUPAC name 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,4a,7,7a-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, is a potent and selective inhibitor of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4). The present disclosure describes a scalable and practical synthesis process for making DMX-5804. The process (1) doesn't rely on transition metals, (2) has reduced duration of reactions, (3) is streamlined with significantly improved yields using low cost raw materials, (4) includes no microwave-assisted reactions, (5) does not require column purification, and (6) generally results in crystalized products having over a 95% purity in each step. The present disclosure also describes DMX-5804 analogs and derivatives for use in inhibiting MAP4K4, and scalable and practical processes for making such DMX-5804 analogs.
专利号:US-4409382-A 优先权日:1982-01-07 标 题:Synthesis and polymerization of phthalonitrile monomers containing multiple phenoxy and sulfone linkages 发明人:KELLER TEDDY M 权利人:US NAVY 摘要:Oligomeric polyarylether sulfone phthalonitrile monomer represented by theormula. ##STR1## wherein A represents an aromatic unit having from 1 to 3 attached or fused aromatic rings, said rings being attached directly or through an aliphatic group, sulfur, or oxygen; and n represents an average value from 1 to 100 prepared by reacting the product of an dialkaline metal bisphenate and 4,4'-dichlorodiphenyl sulfone with 4-nitrophthalonitrile.
专利号:US-5464926-A 优先权日:1993-02-18 标题 :Synthesis and polymerization of oligomeric multiple aromatic ether-containing phthalonitriles 发明人:KELLER TEDDY M 权利人:US ARMY 摘要:Oligomeric monomers are produced by reaction of a bisphenol compound with ther a dihalobenzophenone or a (2,2)bis(4-halophenyl)hexafluoropropane and any other activated halogen containing aromatic compounds in the presence of a base and an appropriate solvent. The resulting oligomeric product, a dialkaline bisphenate terminated salt, is then reacted with 4-nitrophthalonitrile to form an oligomer-based phthalonitrile. These oligomers, in the presence or absence of an curing agent, may then be heated to form high temperature thermosetting polymers. These polymers can potentially be used as advanced materials for composites, as adhesives, and for microelectronic applications.
专利号:CN-115197052-B 优先权日:2022-07-29 标题:A method for catalyzing the synthesis of o-hydroxyphenylacetate using hydroxyapatite
专利号:EP-4352221-A1 优先权日:2021-05-20 标题:Map4k4 inhibitors and methods of synthesis and use thereof
专利号:JP-H03122646-A 优先权日:1989-10-05 标 题:Synthesis method of photopolymerizable compound and liquid photosensitive resin composition
参考标题:Synthesis Of Urea Derivatives From Co 2 And Silylamines 作者:Maotong Xu,Andrew R. Jupp,Maegan S. E. Ong,Katherine I. Burton,Saurabh S. Chitnis,Douglas W. Stephan |发布日期:2019.4.16 摘要:A Series Of Thirty‐three N,N′‐diaryl, Dialkyl, And Alkyl‐aryl Ureas Have Been Prepared In Pyridine Or Toluene By Reaction Of Silylamines With Co2. This Protocol Is Shown To Provide Facile Access To 13C‐labeled Ureas, As Well As Chiral And Macrocyclic Ureas. These Reactions Proceed Through Initial Generation Of The Corresponding Silylcarbamates, Which Subsequently React With Silylamine Under Thermal
合成参考文献
摘要:Ulrich, H., Science of Synthesis, (2004) 17, 101.