CAS: 23978-85-0; Tetrahydrocannabinolic Acid

上下游产品

geranyl diphosphate 2,4-dihydroxyl-6-pentylbenzoic acid CBGA tetrahydr°CannabinolCBD dronabinol Δ8-THC-2-carboxylic acid cannabinol

📜在 柠檬酸体系中,用 甲基叔丁基醚,水 用作溶剂,以585 Mg的收率获得四氢大麻酚酸
参考文献: Process For Purification Of Cannabinoic Acids From Plant Material Extract[fr] Procédé De Purification D'Acides Cannabinoïdes à Partir D'Un Extrait De Matériel Végétal
标题: Process For Purification Of Cannabinoic Acids From Plant Material Extract[fr] Procédé De Purification D'Acides Cannabinoïdes à Partir D'Un Extrait De Matériel Végétal
摘要:本发明涉及一种高效经济的过程,用于从粗制大麻植物材料或所述大麻植物的细胞培养物中纯化大麻酸类物质,更具体地说是thca或cbda,使用离子交换树脂.然后可以将获得的纯化大麻酸类物质脱羧,得到相应的大麻素,即thc或cbd.

专利信息

专利号:WO-2025217205-A1
优先权日:2024-04-08
标 题:Synthesis of (-)-trans-δ9-tetrahydrocannabivarin (δ9-thcv) and analogs thereof
发明人：HAGHDOOST MEHDI; ROBERTS MATTHEW; THOMAS BRIAN; DICKINSON LUKE; NIKITIN EDWARD
权利人:NALU BIO INC
摘要:A method is provided for the synthesis of (-)-trans-Δ9-tetrahydrocannabivarin (Δ9-THCV) and analogs thereof such that in the reaction product, the molar ratio of the Δ9 isomer to incidentally formed Δ8 isomers is greater than 4:1. Synthesis is carried out by combining a selected cannabinoid reactant, e.g., cannabidivarin (CBDV) or an analog thereof, with an acid in a solvent for the cannabinoid reactant, wherein the acid comprises (i) a Lewis acid having an acid softness index value in the range of -10 ΔG0 f, M n+ to ‑150 ΔG0 f, M n+, (ii) a Brønsted acid having a pKa in the range of -4.0 to +4.0, or (iii) a combination of (i) and (ii), under reaction conditions comprising a reaction temperature in the range of ‑0 °C to 25 °C and a reaction time in the range of 1 hour to 24 hours. The reaction is thereafter quenched with base and the solvent removed, wherein the crude reaction product so provided may be purified, e.g., chromatographically purified. Also provided is a method for synthesizing Δ9-THCV that further includes synthesis of the cannabinoid reactant. The invention additionally provides novel cannabinoid compositions that may be synthesized using the aforementioned methodology.

专利号:US-2024228455-A1
优先权日:2021-04-27
标 题 :Synthesis of cbn and cbnv
发明人：KAVARANA MALCOLM J
权利人:TEEWINOT LIFE SCIENCES CORP
摘要:The invention includes chemical synthesis for preparing cannabinol (CBN) and cannabinovarin (CBNV). The process is suitable for inter alia the large-scale synthesis of pharmaceutical grade CBN and CBNV.

专利号:US-11466283-B2
优先权日:2016-08-18
标 题:Plants and methods for increasing and decreasing synthesis of cannabinoids
发明人：ROSCOW ROBERT F
权利人:CANOPY GROWTH CORP
摘要:This disclosure relates to new plants and methods for increasing and decreasing synthesis of cannabinoids. The plants disclosed herein comprise unnatural ratios and concentrations of cannabinoids in plants of genus Cannabis . The methods disclosed herein comprise manipulating the biosynthetic pathway of cannabinoids to produce plants of genus Cannabis with unnatural ratios and concentrations of cannabinoids.

专利号:WO-2024245658-A1
优先权日:2023-05-30
标 题:Process for the synthesis of tetrahydrocannabinolic acid dimethylsiloxane, and tetrahydrocannabinolic acid dimethylsiloxane
发明人：COSKY ERIC S
权利人:TRESCO HOLDING GMBH
摘要:The invention relates to a novel process for the synthesis of tetrahydrocannabinolic acid dimethylsiloxane and tetrahydrocannabinolic acid dimethylsiloxane.

专利号:US-10538790-B2
优先权日:2016-04-04
标题 :Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents
发明人：KAVARANA MALCOLM J; PEET RICHARD C
权利人:TEEWINOT TECH LIMITED
摘要:The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.

专利号:US-2022298522-A1
优先权日:2019-07-30
标 题:Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
发明人：FLAISHMAN MOSHE ARIE; SHAFRAN-TOMER HADAS; COHEN PEER REUT; COHEN ODED
权利人:THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION
摘要:A method of controlling cannabinoid synthesis in a cell or plant or plant part comprising same is provided. The method comprising modulating expression in the cell of at least one polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO: 1-15 and 18-86, the polypeptide modulating cannabinoid synthesis, thereby controlling cannabinoid synthesis in the cell. Also provided are methods of producing cannabinoids and selecting plants producing cannabinoids of interest.