CAS: 188869-05-8; Tert-Butyl 3-Bromo-4-Oxopiperidine-1-Carboxylate

相似化合物

174184-13-5 83877-88-7 95629-02-0

上下游产品

N-叔丁氧羰基-4-哌啶酮 N-Tert-Butyloxycarbonylpiperidin-4-One 79099-07-3

📜4-(三甲基硅基氧基)-5,6-二氢吡啶-1(2H)-甲酸叔丁酯置于n-溴代丁二酰亚胺(Nbs),Sodium Acetate体系中,用 四氢呋喃,水 用作溶剂,化学反应 1.0H,以72%的收率获得3-溴-4-氧代哌啶-1-羧酸叔丁酯
参考文献:有效获得新型对映体纯的甾体δ氨基酸.
标题:有效获得新型对映体纯的甾体δ氨基酸.
摘要:杂环溴代烯醇三氟甲磺酸酯2 Ac与双环烯基stannanes Cis-3和trans-3上的stille和heck偶联的高度化学选择性序列提供了中间体溴代丁二烯4 Ac,产率为73-94%.使用palladacycle 8和另外的双齿配体(例如1,4-双(二苯基膦基)丁烷)的改进型heck偶联方案可以显着降低催化剂的载量,同时仍以非常好的收率获得杂环1,3,5-己三烯5 Ac( 71-94%).在优化的微波加热方案下,溶液中不对称取代的1,3,5-己三烯5 Ac经历了6Pi电环化反应,生成甾体四环顺式7Ac和反式7B(59-69%).四环顺式-7 Ac是随后的1,5-氢转移到热力学上更稳定的产物,更高度取代的二烯单元.叔丁基的去除提供了新的甾族δ-氨基酸9A和δ-氨基酸衍生物9B,C,产率高(76-86%).
Doi:10.1002/chem.200601076

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-2019308969-A1
优先权日:2016-11-11
标 题 :Heterocyclic modulators of lipid synthesis

专利号:US-2022296605-A1
优先权日:2011-03-08
标 题 :Heterocyclic modulators of lipid synthesis