CAS: 182281-01-2; (4-((Tetrahydro-2H-Pyran-2-yl)Oxy)Phenyl)Boronic Acid

上下游产品

CAS号36603-49-3 2-(4-溴苯氧基)四氢-2H-吡喃 | CAS号121-43-7 硼酸三甲酯 | CAS号594-19-4 叔丁基锂 | CAS号5419-55-6 硼酸三异丙酯 | CAS号110-87-2 3,4-二氢-2H-吡喃 | CAS号7732-18-5 水 | CAS号106-41-2 对溴苯酚

2-对溴苯氧基四氢吡喃置于正丁基锂,异丙醇频哪醇硼酸酯体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 1.5H,以82%的收率获得[4-(四氢吡喃-2-基)氧基]苯硼酸
参考文献:Recoverable Fluorescence Chemosensors For Ni2+ Ions Based On Hydrogen-Bonded Side-Chain Copolymers Presenting Pendent Benzoic Acid And Pyridyl Receptor Units
标题:Recoverable Fluorescence Chemosensors For Ni2+ Ions Based On Hydrogen-Bonded Side-Chain Copolymers Presenting Pendent Benzoic Acid And Pyridyl Receptor Units
摘要:在本研究中,我们合成了新型荧光共轭均聚物p1和p4以及含质子受体(吡啶受体)m1单体单元和质子供体(苯甲酸)m2单体单元的共聚物p2和p3,并将它们作为可回收的ni2+离子化学传感器进行了研究(基于通过改变氢键的程度来调节m1和m2基团之间的荧光能量转移).通过使用吡啶单体m1和苯甲酸单体m2的不同摩尔比,共聚物p2和p3中可用的(即非氢键的)吡啶受体的水平被修改.通过荧光淬灭行为可以明显看出荧光均聚物p1和p4以及共聚物p2和p3对ni2+离子的强螯合作用;特定淬灭常数(ksv)按p1 > P2 > P3 > P4的顺序减小,这与吡啶受体的摩尔比趋势一致.当我们加入第三种成分环糊精(cd)来封闭苯甲酸基团,从而破坏共聚物p2和p3中m1和m2基团之间的氢键时,可回收化学传感器共聚物中可用的吡啶受体水平增加,导致p2 + Cd,P3 + Cd和混合物(p1/p4)+ Cd系统的淬灭常数相对较高.荧光衰减实验表明,加入cd还提高了共聚物p2和p3对ni2+离子的荧光淬灭效率.这种超分子(氢键)侧链荧光共聚物可能具有作为可回收和/或可调节化学传感器的实际应用性.
Doi:10.1039/c2Jm31367G

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.