CAS: 1583-59-1; 2,2-Difluorobenzo[d][1,3]Dioxole

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胡椒环置于fluorine,三氟乙酸体系中,用 乙腈 用作溶剂,以90%的收率获得2,2-二氟-1,3-苯并二恶茂
参考文献:一种二氟胡椒环的制备方法
标题:一种二氟胡椒环的制备方法
摘要:本发明涉及药物中间体的制备方法,特别提供了一种二氟胡椒环的制备方法,其合成过程如下:采用微通道反应器,将胡椒环溶液连续均匀泵入a模块进行预冷;同时将氟气混合气体连续均匀泵入b模块进行预冷;依次在c,D,E及f模块中混合反应,反应温度控制在‑40oc‑20°C,在5S‑10Min保留时间下收集产物;产物经水洗,精馏分离纯化得到二氟胡椒环.该方法制备二氟胡椒环具有原子经济性高,反应快速,成本低,污染小,环保安全等优点.

专利信息

专利号:US-5432290-A
优先权日:1989-10-09
标题 :Process for the preparation of 2,2-difluoro-1,3-benzodioxole
发明人：CASADO MICHEL; CROCHEMORE MICHEL; LANGLOIS BERNARD
权利人:RHONE POULENC CHIMIE
摘要:A process for the preparation of 2,2-difluoro-1,3-benzodioxole from 2,2-dichlorol,3-benzodioxole. 2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride. 2,2-Difluoro-1,3-benzoxodiole is an intermediate compound which is used particularly for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-8470889-B2
优先权日:2008-11-26
标题:Hybrid-ionone and curcumin molecules as anticancer agents
发明人：Wu jian hui; BATIST GERALD; ZHOU JINMING; GENG GUOYAN; LIN RONGTUAN; LI YI
权利人:Wu jian hui; BATIST GERALD; ZHOU JINMING; GENG GUOYAN; LIN RONGTUAN; LI YI; TRT PHARMA INC
摘要:The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.

专利号:RU-2072991-C1
优先权日:1991-10-09
标题:3-phenylpyrazole derivatives, method of synthesis of 3-phenylpyrazole derivatives and fungicide composition

专利号:CN-103497180-B
优先权日:2013-09-24
标题:Synthesis of 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile

专利号:CN-103497180-A
优先权日:2013-09-24
标 题 :Synthesis of 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile