CAS: 150-13-0; 4-Aminobenzoic Acid

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CAS号62-23-7 对硝基苯甲酸 | CAS号6427-66-3 对叠氮苯甲酸 | CAS号201230-82-2 carbon monoxide | CAS号540-37-4 对碘苯胺 | CAS号619-44-3 4-碘苯甲酸甲酯 | CAS号7681-52-9 次氯酸钠 | CAS号6757-31-9 4-氨基甲酰苯甲酸甲酯 | CAS号59247-47-1 4-溴苯甲酸叔丁酯 | CAS号586-91-4 偶氮苯-4,4-二羧酸 | CAS号619-58-9 对碘苯甲酸 | CAS号103853-88-9 4-羟基-2-甲基-5-喹啉羧酸 | CAS号108199-09-3 [4-[(7-chloroqu... | CAS号107920-79-6 4-苯磺酰氨基苯甲酸甲酯 | CAS号110073-82-0 2-苯基-5-吲哚羧酸 | CAS号109506-41-4 4-(hexanoylamin... | CAS号42823-46-1 4-胍基苯甲酸盐酸盐 | CAS号35461-98-4 4-(2-呋喃)苯甲酸 | CAS号555-06-6 对氨基苯甲酸钠 | CAS号5429-28-7 4-二乙氨基苯甲酸 | CAS号7409-09-8 4-(乙基氨基)苯甲酸

乙烷,三氯氟-置于盐酸,Potassium Permanganate,Magnesium Sulfate体系中,用 水 用作溶剂,化学反应 22.17H,反应生成对氨基苯甲酸
参考文献:新型 4-氨基喹啉:结核分枝杆菌烯酰基载体蛋白还原酶的合成,抑制,抗结核活性,Sar 和临床前评价
标题:新型 4-氨基喹啉:结核分枝杆菌烯酰基载体蛋白还原酶的合成,抑制,抗结核活性,Sar 和临床前评价
摘要:在此合成了一系列 4-氨基喹啉,试图优化和研究与 Labio-17 生物活性相关的结构特征,Labio-17 是结核分枝杆菌 Nadh依赖性烯酰基-酰基载体蛋白还原酶 ( Mt Inha) 抑制剂,先前由虚拟-配体筛选方法.构效关系导致了新型亚微摩尔mt Inha 抑制剂和强效抗结核药物的产生.与 Labio-17 相比,先导化合物作为酶抑制剂的效力高 87 倍,对结核分枝杆菌h37Rv 菌株的效力高 32 倍.这些分子对多重耐药菌株也有活性,对哺乳动物细胞没有明显毒性,并显示出非常好的体外adme 概况.此外,这些化合物在结核病 (Tb) 感染的细胞内模型中具有活性,没有表现出遗传毒性信号,令人满意的吸收参数并且没有体内急性毒性.最后,用选定的 4-氨基喹啉治疗两周在结核病小鼠模型中产生抑菌作用.总而言之,这些发现表明该化学类别可能为未来开发药物敏感和耐药的结核病治疗提供候选药物.
Doi:10.1016/j.Ejmech.2022.114908

专利信息

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2012165520-A1
优先权日:2010-12-23
标题:Process for the synthesis of prodrugs of opioids
发明人：MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.

专利号:US-4801744-A
优先权日:1985-03-01
标 题 :Catalytic synthesis of urea from carbon monoxide and amine compound
发明人：HERMAN JEAN-JACQUES; LECLOUX ANDRE
权利人:SOLVAY
摘要:Process for the catalytic synthesis of nitrogen-containing organic compounds, comprising the reaction of carbon monoxide with at least one amino compound in a reaction mixture containing a catalyst based on selenium and a substituted pyridine. The process is particularly suitable for the synthesis of ureas and of their polymers.

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-2024294464-A1
优先权日:2021-10-27
标题 :Synthesis of restrained complexing agents
发明人：WONG NICHOLAS; GOSSELIN FRANCIS
权利人:GENENTECH INC
摘要:Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.