CAS: 13726-14-2; 4-Chloro-3-Methoxyaniline

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1009-36-5 113206-03-4 98446-49-2

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CAS号1009-36-5 2-氯-5-硝基苯甲醚 | CAS号1984-58-3 2,5-二氯苯甲醚 | CAS号7439-89-6 铁粉 | CAS号97-52-9 2-甲氧基-4-硝基苯胺 | CAS号18113-07-0 3-甲氧基-4-氯苯酚 | CAS号7051-13-0 1-氯-2,4-二甲氧基苯 | CAS号6358-06-1 2-氯-5-氨基苯酚 | CAS号16817-43-9 5-溴-2-氯苯甲醚 | CAS号13726-16-4 4-氯-3-甲氧基苯甲醛 | CAS号13726-17-5 (4-氯-3-甲氧基苯基)甲醇 | CAS号13726-18-6 1-chloro-4-(chl... | CAS号13726-19-7 2-(4-氯-3-甲氧基苯基)乙酸 | CAS号13726-21-1 4-氯-3-甲氧基苯乙腈 | CAS号161949-50-4 2-氯-5-碘苯甲醚

📜2,5-二氯苯甲醚置于iron(III) Nitrate Nonahydrate,氨,Sodium体系中,用 正己烷 用作溶剂,化学反应 2.0H,以99%的收率获得3-甲氧基-4-氯苯胺
参考文献:7-(2-苯氧基乙氧基)-4(1H)-喹诺酮类的合成,抗疟活性及构效关系
标题:7-(2-苯氧基乙氧基)-4(1H)-喹诺酮类的合成,抗疟活性及构效关系
摘要:Ici 56,780 ( 5 ) 在啮齿动物疟疾模型中显示出因果预防和血液分裂活性(ed 50 = 0.05 Mg/kg),但在感染伯氏疟原虫的小鼠中迅速获得了寄生虫学抗性.在此,我们描述了针对多药耐药恶性疟原虫的 Ec 50低至 0.15 Nm的5类似物的合成.通过在 7-(2-Phenoxyethoxy)-4(1 H )-Quinolone 核心的 3 位引入邻位取代的芳基部分,实现了对 Atovaquone 的低交叉阻力指数 (Ri) 的最佳活性.
Doi:10.1021/jm200718M

专利信息

专利号:US-2024182421-A1
优先权日:2021-03-19
标题 :Synthesis of endochin-like quinolones
发明人：RISCOE MICHAEL K; NILSEN AARON; JIN HAIHONG; POU SOVITJ; WINTER ROLF W; DODEAN ROZALIA ANA; LIEBMAN KATHERINE M
权利人:UNIV OREGON HEALTH & SCIENCE; US GOV VETERANS AFFAIRS
摘要:Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:WO-9509156-A1
优先权日:1993-09-27
标 题 :Processes and intermediates for the enantiospecific synthesis of benzo(d)naphth(2.1-b)azepines

专利号:WO-2022197979-A1
优先权日:2021-03-19
标题:Synthesis of endochin-like quinolones

专利号:EP-4308109-A1
优先权日:2021-03-19
标 题:Synthesis of endochin-like quinolones

专利号:CN-117042768-A
优先权日:2021-03-19
标题:Synthesis of doxine-like quinolones