CAS: 13433-09-5; (S)-3-Amino-4-(((S)-1-Carboxy-2-Phenylethyl)Amino)-4-Oxobutanoic Acid

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📜3-苯基-L-丙氨酸苄酯置于钯 氢气,溶剂黄146体系中,用 乙酸乙酯 用作溶剂,化学反应生成L-冬胺基乙酸-L-苯丙胺基乙酸
参考文献:一些二肽的结构-味道关系.
标题:一些二肽的结构-味道关系.
摘要:
Doi:10.1021/ja01038A046

专利信息

专利号:US-2005069928-A1
优先权日:2003-08-04
标 题 :Methods for synthesis of defined polynucleotides
发明人：NELSON JEFFREY S; MULLIGAN JOHN T; TABONE JOHN C
权利人:BLUE HERON BIOTECHNOLOGY INC
摘要:Disclosed is a significantly improved synthetic method of producing a set of mutagenized progeny polynucleotides which contain at least one substituted codon encoding for each of the 20 naturally encoded amino acids or any selected subset thereof. This in turn, similarly provides a method for producing from a parental template polypeptide, a set of mutagenized progeny polypeptides in which all 20 naturally encoded amino acids is represented at each original amino acid position or any selected subset thereof. The methods described herein enable the synthesis of defined, complex mixtures of oligonucleotides, in instances where the incorporation of degenerate bases is impractical. These oligonucleotide mixtures are useful for a variety of applications such as recombination methods, site-saturation mutagenesis, or the like.

专利号:WO-0037486-A1
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO; QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-α- and β-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-6617127-B2
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER J L M; SONKE THEODORUS; WAGNER ADOLF F V
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-alpha-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-alpha- and beta-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:EP-1140982-B1
优先权日:1998-12-22
标 题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl- alpha -L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl- alpha - and beta -L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-5144073-A
优先权日:1988-08-31
标 题 :Process for preparation of dipeptides
发明人：HUBBS JOHN C
权利人:HUBBS JOHN C
摘要:Disclosed is a process for synthesis of a dipeptide such as N-acetyl-L- alpha -aspartyl-L-phenylalanine methyl ester wherein one amino acid serves as a chiral template which allows for synthesis of a second amino acid residue to form said dipeptide. The process involves several novel steps such as a nucleophile addition step. In addition, several novel intermediates are described.

专利号:US-8034969-B2
优先权日:2003-05-06
标 题:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors
发明人：PRAKASH INDRA; FURLONG KENNETH E; JACKSON III HANDLEY E
权利人:NUTRASWEET CO
摘要:N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.