CAS: 1201593-65-8; (S)-2-Amino-3-Cyclobutylpropanoic Acid

相似化合物

174266-00-3 478183-63-0 478183-62-9

上下游产品

(Bromomethyl)cyclobutane 2-acetylaminomalonic acid diethyl ester cyclobutylmethyl 4-methylbenzenesulfonate cyclobutanemethanol 5-chloro-3-fluoro-2(1H)-pyridinone 2,5-dichloro-3-fluoro-4-iodopyridine 5-chloro-2,3-difluoropyridine 3-amino-2,5-dichloropyridine 5-chloro-2,3-difluoropyridine 2,5-dichloro-3-fluoro-4-iodopyridine 4-(5-chloro-3-fluoropyridin-2-yloxy)-phenol

专利信息

专利号:US-2023212788-A1
优先权日:2020-03-26
标 题:New method for automated on-demand biomolecular array synthesis
发明人：ZHANG YIXIN; LIN WEILIN
权利人:UNIV DRESDEN TECH
摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.

专利号:US-7091313-B2
优先权日:1999-08-30
标 题:Synthesis of template-fixed β-hairpin loop mimetics
发明人：ROBINSON JOHN A; OBRECHT DANIEL
权利人:POLYPHOR AG
摘要:Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimic flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:CA-2382931-C
优先权日:1999-08-30
标题:Synthesis of template-fixed .beta.-hairpin loop mimetics

专利号:CN-115698714-A
优先权日:2020-03-26
标题 :New method for automated on-demand synthesis of biomolecular arrays

专利号:EP-4192512-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates