CAS: 112-82-3; 1-Bromohexadecane

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CAS号36653-82-4 十六醇 | CAS号66143-65-5 hexadecyl 3-(di... | CAS号4860-03-1 氯代十六烷 | CAS号83634-89-3 hexadecyl 3-(di... | CAS号83634-99-5 hexadecyl 4-(di... | CAS号83486-05-9 dibromo(hexadec... | CAS号143-27-1 十六胺 | CAS号18049-99-5 N-Hexadecyl-4-t... | CAS号111301-34-9 triacont-13-yn-1-ol | CAS号38775-38-1 十六烷基磺酰氯 | CAS号3312-77-4 十六烷基硫醚 | CAS号4721-17-9 十六烷基膦酸 | CAS号66143-73-5 hexadecyl thi°C... | CAS号4426-87-3 异硫氰酸十六酯 | CAS号4673-33-0 3-十六烷氧基丙胺 | CAS号57-09-0 十六烷基三甲基溴化铵 | CAS号141625-25-4 dibutyl-hexadec... | CAS号143399-31-9 10-hexadecylphe...

1-十六烷醇置于三乙胺,Potassium Bromide体系中,用 二氯甲烷,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 5.0H,反应生成溴代十六烷
参考文献:乙烯基磺酸盐:用于偶联和去偶联化学的点击功能及其应用
标题:乙烯基磺酸盐:用于偶联和去偶联化学的点击功能及其应用
摘要:术语"偶联和解偶联(cad)"化学术语是指需要有效形成键并随后在两个基团之间裂解的应用.在这种情况下,已报道了乙烯基磺酸盐(vso)基团作为cad化学的有效工具的范围.偶联步骤依赖于将多种亲核试剂加至乙烯基磺酸盐的michael型加成的咔嗒声,这是一种有价值的方法.在温和条件下使用模型vso衍生物获得的高收率已证明了该策略的可行性.通过不同亲核试剂的亲核取代(对于烷基vso基团)或通过水解(对于烷基和芳基vso而言)裂解所得的磺酸盐加合物是脱偶联步骤的成功策略,前者是最有希望的,因为反应是在较温和的条件下与巯基亲核试剂进行的.此外,Click Vso偶联化学被证明与click Cuaac反应正交,这使vso-Cad方法学能够为双击模块化策略制备异双功能可点击和可裂解的连接子.在两个生物学上相关的例子中证明了vso-Cad化学的潜力:在与生物系统相容的条件下,磺酸盐与谷胱甘肽(gsh)的解偶
Doi:10.1002/adsc.201600628

专利信息

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-10751285-B1
优先权日:2019-05-14
标题 :Synthesis of C resorcinarene based novel amphiphilic supramolecular macrocycle as nano-scale drug loading system
发明人：SHAH MUHAMMAD RAZA; ALI IMDAD; ALI HEYAM SAAD; EL-HAJ BABIKER M; IMRAN MUHAMMAD
权利人:SHAH MUHAMMAD RAZA; ALI IMDAD; ALI HEYAM SAAD; EL-HAJ BABIKER M; IMRAN MUHAMMAD
摘要:A drug delivery system comprising the synthesis of resorcinarene based novel amphiphilic supramolecular macrocycle that is capable of self-assembling in nano-scale vesicles upon its contact with aqueous medium and its use as nano-drug loading vehicle when mixed with cholesterol (2:1 ratio w/w).

专利号:WO-2025109557-A1
优先权日:2023-11-24
标题:Process for the synthesis of monoesters of ethylenediaminetetraacetic acid
发明人：TERAZONO YUICHI
权利人:NUTRIEN AG SOLUTIONS CANADA INC
摘要:A process for the synthesis of a compound of Formula (I) is provided. (I) wherein R is selected from the group consisting of alkyl, alkenyl, alkynyl, and steroidyl. The process comprises reacting a compound of Formula (IIa), Formula (IIb) or a mixture thereof with a compound of Formula R-X, to obtain a compound of Formula (IIIa), a compound of Formula (IIIb) or a mixture thereof, wherein A+ is a cesium cation, a quaternary ammonium cation or a quaternary phosphonium cation, and X is a leaving group; and reacting the compound of Formula (IIIa), compound of Formula (IIIb) or mixture thereof with an acid to obtain a reaction product which comprises the compound of Formula (I). (IIa) (IIb) (IIIa) (IIIb)

专利号:US-4594426-A
优先权日:1980-01-17
标题 :Benzoxazole derivative intermediates for synthesis of dye releasing redox compounds
发明人：FUJITA SHINSAKU; KOYAMA KOICHI; INAGAKI YOSHIO
权利人:FUJI PHOTO FILM CO LTD
摘要:Benzoxazole derivatives represented by general formula (I) which are intermediates for synthesis of o-sulfonamidophenol derivatives useful as dye releasing redox compounds in a color diffusion transfer color image forming process: ##STR1## wherein R 1 and R 2 , which may be the same as or different from each other, each represents an alkyl group or an aryl group or they may combine and form a ring; R 3 represents a hydrogen atom, an alkyl group or an aryl group; R 4 represents an alkyl group or an aryl group; R 5 represents an alkyl group, an alkoxy group, an alkylthio group, an arylthio group, a halogen atom or an acylamino group, or --CR 1 R 2 R 3 and R 5 may combine and form the nucleus ##STR2## which is condensed at the 6- and the 7-positions of the benzoxazole nucleus; and n is 0, 1 or 2.

专利号:US-8153615-B2
优先权日:2005-06-10
标 题:Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds
发明人：BITTMAN ROBERT; BYUN HOE-SUP; ARTHUR GILBERT
权利人:BITTMAN ROBERT; BYUN HOE-SUP; ARTHUR GILBERT
摘要:The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.