CAS: 1117-77-7; Methyl 2-Acetamidoacetate
该化合物是一种N-乙酰甘油的甲基酯衍生物,通常用于有机合成和浸泡化学,该化合物因其反应性酯组而成为多用途建筑块,能够产生高效的相互碰撞反应,在温和条件下稳定,在普通有机溶剂中溶解性,提高了实验室应用的实用性.甲基N-乙酰甘油因其在改变peptids和准备衍生物,提高生物利用率或功能特性方面的作用而特别受到重视.该酯有助于选择性反应,使其成为药用化学和生物化学研究的有用中间体.其直接合成和处理进一步有助于其在学术和工业环境中的实用性.
- 英文名称Methyl 2-Acetamidoacetate
- 中文名称(乙酰氨基)乙酸甲酯
- IUPAC名称methyl acetylglycinate
- 其它别名Methyl N-Acetylglycinate; (Acetylamino)Acetic Acid Methyl Ester; Aceturic Acid Methyl Ester; N-Acetylglycine Methyl Ester; Methyl 2-Acetamidoacetate; Glycine, N-Acetyl-, Methyl Ester; Methyl N-Acetylglycinate Usp/ep/bp; Ac-Gly-Ome
- CAS编号1117-77-7
- MFCD编号:MFCD00090795
- EINECS号:634-588-0
- 分子式:C5H9NO3分子量:131.13
- 产品CID: 152256
- 产品分类有机原料→分子砌块→脂肪链类化合物
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CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号67-56-1 甲醇 | CAS号543-24-8 N-乙酰甘氨酸 | CAS号61985-23-7 甲基1H-咪唑-1-羧酸甲酯 | CAS号616-34-2 甘胺酸甲酯 | CAS号1816-92-8 2-叠氮基乙酸甲酯 | CAS号507-09-5 硫代乙酸 | CAS号108-24-7 乙酸酐 | CAS号372-48-5 2-氟吡啶 | CAS号88001-14-3 | CAS号543-24-8 N-乙酰甘氨酸 | CAS号289-95-2 嘧啶 | CAS号60676-51-9 (Z)-2-乙酰氨基-3-苯基丙烯酸甲酯 | CAS号7606-79-3 乙酰甘氨酸甲基酰胺 | CAS号66299-28-3 methyl 2-acetam... | CAS号79722-83-1 methyl 2-acetam... | CAS号94726-23-5 methyl 1-methyl...合成工艺路线路线简述
- 合成目标产物 Methyl N-Acetylglycinate 主要起始原料 Glycine Methyl Ester Hydrochloride And Acetyl Chloride
- (文献来源)合成步骤主要原料 Glycine Methyl Ester Hydrochloride 和 Acetyl Chloride
📜以 Neat (No Solvent) 用作溶剂,以81%的收率获得(乙酰氨基)乙酸甲酯
参考文献:Chemoselectivity In Coupling Of Azides With Thioacids In Solution-Phase And Solvent-Free Conditions
标题:Chemoselectivity In Coupling Of Azides With Thioacids In Solution-Phase And Solvent-Free Conditions
摘要:Solvent-Free Rapid Coupling Of Monothiocarboxylic Acid With Azide Affords Carboxamide Chemoselectively. Triphenyl Phosphine Included As An Additive Influences The Chemoselectivity,Yielding Carboxamide And Thioamide. Similar Variation In The Chemoselectivity Is Observed In The Absence And Presence Of Triphenyl Phosphine In Solution-Phase Methodology. Rapidity And Ecofriendliness Of The Solvent-Free Approach To Yield The Products In Just 15 Min Is Noteworthy Compared To The Solution-Phase Protocol,Which Has A Long Reaction Time (1-3 Days).
Doi:10.1080/00397911.2011.606043
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2915110000-甲酸
2915211900-乙酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.
专利号:US-2013005962-A1
优先权日:2006-12-31
标题 :Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments
专利号:EP-1984384-B1
优先权日:2006-02-17
标 题:Conotoxin analogues, and methods for synthesis of intramolecular dicarba bridge containing peptides
专利号:EP-2114909-A2
优先权日:2006-12-31
标 题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments
专利号:MX-PA03004168-A
优先权日:2000-12-13
标题 :SYNTHESIS OF P-QUIRAL BISPHOSPHOLAN LIGANDS AND THEIR COMPLEXES WITH TRANSITIONAL METALS FOR USE AS ASYMETRIC HYDROGENATION CATALYSTS.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2012) 4, 431.
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