CAS: 104344-23-2; Bisoprolol Fumarate

上下游产品

bisoprolol (2E)-but-2-enedioic acid2-(1-methylethoxy)-ethanol

比索洛尔杂质12 反应生成富马酸比索洛尔
参考文献:Phenoxy-Amino-Propanols
标题:Phenoxy-Amino-Propanols
摘要:新的苯氧-氨基-丙醇类化合物的化学式为##str1##其中r.Sup.1为烯基,炔基,烷氧基烷基或烯氧基烷基,每种情况下有2-6个碳原子,或环烷基,有3-8个碳原子;R.Sup.2为烷基或羟基烷基,每种情况下有1-6个碳原子,环烷基,有3-8个碳原子,芳基烷基或芳基烷基,其中芳基基团经烷基,烷氧基,羟基,氟和/或氯单取代或经亚甲二氧基单取代,每种情况下总共有7-15个碳原子,以及其生理上可接受的酸盐,表现出包括对心率和血压的异丙肾上腺素拮抗等各种药理特性.

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:WO-2016135616-A1
优先权日:2015-02-27
标题:An improved process for the preparation of bisoprolol and its intermediate
发明人：MORTHALA RAGHAVENDAR RAO; GHARPURE MILIND; JAGTAP ASHUTOSH; MHASKAR MAHESH; KRISHNMURTHY DHILEEPKUMAR
权利人:PIRAMAL ENTPR LTD
摘要:The present invention provides an improved process for the preparation of 4-((2-isopropoxy ethoxy) methyl) phenol compound (I), used as an intermediate in many organic synthesis; particularly a key intermediate for the synthesis of l-[4[2(l-methylethoxy) ethoxy methyl] phenoxy]-3-(l-methylethylamino)-propan-2-ol; commonly known as Bisoprolol or its pharmaceutically acceptable salts. The process comprises reacting the 4-hydroxybenzyl alcohol (II) with the 2-isopropoxyethanol (III) in the presence of activated silica and optionally, in the presence of solvent.

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2009137678-A1
优先权日:2005-07-06
标 题:High yield synthesis methods for producing organic salts of strontium
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T
摘要:New organic salts of strontium and methods of synthesizing such salts with high purity, high yields and with short processing times, at neutral conditions and at low reaction temperature, such as a temperature at or below 50° C.

专利号:US-8440695-B2
优先权日:2005-11-09
标 题:Use of chloroquine to treat metabolic syndrome
发明人：KASTAN MICHAEL B; SEMENKOVICH CLAY F; SCHNEIDER JOCHEN
权利人:KASTAN MICHAEL B; SEMENKOVICH CLAY F; SCHNEIDER JOCHEN; ST JUDE CHILDRENS RES HOSPITAL; UNIV WASHINGTON
摘要:The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption.

专利号:CN-104876806-A
优先权日:2015-05-26
标 题:A new method for the synthesis of important intermediates of bisoprolol