CAS: 94-99-5; 2,4-Dichloro-1-(Chloromethyl)Benzene

上下游产品

CAS号626-16-4 间二氯苄 | CAS号108-88-3 甲苯 | CAS号95-73-8 2,4-二氯甲苯 | CAS号50264-69-2 氯尼达明 | CAS号5013-77-4 N-(2,4-二氯苄基)甲胺 | CAS号95-00-1 2,4-二氯苯甲胺 | CAS号403-33-8 对氟苯甲酸甲酯 | CAS号51619-56-8 1-(2,4-二氯苯基)哌嗪 | CAS号90390-15-1 N-乙基-2,4-二氯苄胺 | CAS号30067-11-9 (2,4-二氯苯基)乙醛 | CAS号874-42-0 2,4-二氯苯甲醛 | CAS号88691-50-3 (2,4-二氯苯基)甲磺酰氯 | CAS号70627-17-7 4-(2,4-二氯-苄氧基)-苯甲醛

2,4-二氯苄醇置于氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,以96.1%的收率获得产物2,4-二氯氯苄
参考文献:一种制备6-氯-2-甲基-2H-吲唑-5-胺的方法
标题:一种制备6-氯-2-甲基-2H-吲唑-5-胺的方法
摘要:本发明公开了一种制备6‑氯‑2‑甲基‑2H‑吲唑‑5‑胺的方法,属于药物合成技术领域,解决了现有合成方法存在的收率低,成本高,难以实现规模化生产的问题.本发明制备方法如下:式ⅲ或式ⅷ化合物经卤代,与甲基肼取代反应后进行分子内环化得到式ⅵ或式ⅺ化合物;式ⅵ化合物经氧化脱氢,成硝酸盐后发生硝化反应得到式ⅱ化合物;式ⅺ化合物经氧化脱氢得到式ⅱ化合物;式ⅱ化合物经催化氢化还原硝基得到目标产物.本发明方法相较于以往的报道,所用原辅材料及试剂价廉易得,选择性好,收率高,有效降低成本;生产过程绿色环保,安全性高;中间体及产物纯化方法简单,适合规模化生产.

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-2002161234-A1
优先权日:1990-11-19
标 题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors